{"id":"W2990636216","doi":"10.1182/blood.v112.11.2020.2020","title":"Recombinant Protein Infusion and Hydrodynamic Plasmid Delivery Strategies Provide Distinct and Complementary Approaches to the Characterization of Variant Forms of Von Willeband Factor (VWF) in VWF Knockout Mice.","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Von Willebrand factor; ADAMTS13; Von Willebrand disease; Platelet; Knockout mouse; Chemistry; Hemostasis; Cleavage (geology); Recombinant DNA; Phenotype; Wild type; Molecular biology; Bleeding time; In vivo; Metalloproteinase; Immunology; Mutant; Biology; Gene; Matrix metalloproteinase; Internal medicine; Genetics; Biochemistry; Medicine; Platelet aggregation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009764318,0.000946493,0.0004788465,0.001344016,0.0002518633,0.0008947653,0.0005914777,0.001283265,0.001635305],"category_scores_gemma":[0.0006178283,0.0003999094,0.0006150781,0.0003703975,0.000922602,0.0007146131,0.000657092,0.001929221,0.001026541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003711476,"about_ca_system_score_gemma":0.0002906301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000192392,"about_ca_topic_score_gemma":0.0002153823,"domain_scores_codex":[0.9990543,0.0001946572,0.0001542356,0.000245546,0.0002035811,0.00014772],"domain_scores_gemma":[0.999158,0.0001467913,0.0003474051,0.0001212572,0.00006664604,0.0001597571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009005066,0.00008232622,0.0001008616,0.00003234433,0.000005145031,0.00005799156,0.00002369876,0.00003934074,0.9979076,0.0005206739,0.00003528863,0.001104656],"study_design_scores_gemma":[0.00004165587,0.0008286768,0.001377392,0.0000105177,0.00003521035,0.001050991,0.00002370469,0.0007482831,0.9919634,0.0001548758,0.0037475,0.00001789697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8210735,0.003096024,0.1669022,0.0005611275,0.0003868285,0.0009163095,0.002263224,0.001074378,0.003726306],"genre_scores_gemma":[0.8046529,0.003803199,0.1767966,0.0003742797,0.0001463067,0.001554553,0.00321289,0.0007073187,0.00875198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001635305,"threshold_uncertainty_score":0.005470693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03018590746561537,"score_gpt":0.2134985028224544,"score_spread":0.1833125953568391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}