{"id":"W2990639324","doi":"10.1101/851089","title":"Balancing Selection at <i>HLA-G</i> Modulates Fetal Survival, Preeclampsia and Human Birth Sex Ratio","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kwantlen Polytechnic University; Simon Fraser University","funders":"Astellas Foundation for Research on Metabolic Disorders; Päivikki ja Sakari Sohlbergin Säätiö; Karolinska Institutet; Astellas Pharma; Great Britain Sasakawa Foundation; Suomen Lääketieteen Säätiö; Japan Eye Bank Association; Japan Society for the Promotion of Science; Helsingin Yliopisto; Eye Bank Association of America","keywords":"Human leukocyte antigen; Offspring; Fetus; HLA-G; Biology; Preeclampsia; Population; Balancing selection; Pregnancy; Immunology; Sex ratio; Antigen; Genetics; Medicine; Major histocompatibility complex","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006366689,0.0001657256,0.0002967397,0.0003048992,0.0001642243,0.0005127276,0.0001892444,0.0003617609,0.007573592],"category_scores_gemma":[0.001928914,0.00007205686,0.0001448668,0.0003227674,0.0001821614,0.0001732328,0.0001773903,0.0003344533,0.001214576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001325241,"about_ca_system_score_gemma":0.0001361171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004660362,"about_ca_topic_score_gemma":0.0004265436,"domain_scores_codex":[0.9997994,0.0000725721,0.00001426227,0.00005319574,0.00004425671,0.0000162789],"domain_scores_gemma":[0.9994299,0.0002455013,0.0001411205,0.00004829208,0.00006572359,0.00006943383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003246571,0.0001203435,0.5279246,0.001260821,0.0005795836,0.001785491,0.0007187374,0.001312547,0.1691374,0.006220488,0.1380292,0.1496642],"study_design_scores_gemma":[0.0001070085,0.0003968241,0.9155481,0.0001617157,0.0002646256,0.003232029,0.0004023667,0.002757073,0.03304956,0.006240599,0.03778443,0.00005552136],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9307528,0.01385192,0.007585805,0.01717106,0.002776693,0.00004134942,0.01781593,0.0006059126,0.009398354],"genre_scores_gemma":[0.9804171,0.002646592,0.001979583,0.001536722,0.000995627,0.0000392473,0.003516879,0.000144712,0.008723403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007573592,"threshold_uncertainty_score":0.02533621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01093223470885066,"score_gpt":0.2116111971556922,"score_spread":0.2006789624468416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}