{"id":"W2990671488","doi":"10.1101/860676","title":"The Topology of Mutated Driver Pathways","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Topological and Geometric Data Analysis","field":"Computer Science","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Myeloid leukemia; Glioblastoma; Leukemia; Computational biology; Cancer; Cancer research; Biology; GRASP; Computer science; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008088386,0.0002840047,0.0004291582,0.005150917,0.0007196684,0.002892321,0.0005868082,0.00054217,0.003411368],"category_scores_gemma":[0.005326657,0.0002404305,0.0004014389,0.002235759,0.00186947,0.002367428,0.002070231,0.0007716233,0.0003594183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000749754,"about_ca_system_score_gemma":0.000359914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000698655,"about_ca_topic_score_gemma":0.0004217039,"domain_scores_codex":[0.9991806,0.0002378889,0.00005208377,0.0001581686,0.0002742967,0.00009691762],"domain_scores_gemma":[0.9966735,0.001338594,0.0007716762,0.0003328879,0.0004445344,0.0004389136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0005588849,0.00008976788,0.05884764,0.0004461823,0.0001463467,0.001248938,0.00180083,0.06297076,0.02960707,0.7859066,0.002960771,0.05541631],"study_design_scores_gemma":[0.00003477216,0.0001935579,0.03177109,0.00009481096,0.00006757228,0.002082617,0.001492067,0.1390533,0.009412361,0.8019024,0.01382255,0.00007298229],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9371591,0.0004913684,0.05295905,0.0005764566,0.00002159846,0.00002619273,0.001412184,0.0001808482,0.007173192],"genre_scores_gemma":[0.9844843,0.0002984896,0.01289548,0.0000404132,0.00002138157,0.00002924971,0.001388167,0.0000353524,0.0008073524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005150917,"threshold_uncertainty_score":0.0114122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01564830222118428,"score_gpt":0.2131187518367653,"score_spread":0.1974704496155811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}