{"id":"W2990681219","doi":"10.1038/s41598-019-54001-8","title":"Long-term monitoring in a microfluidic system to study tumour spheroid response to chronic and cycling hypoxia","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada; Canadian Institutes of Health Research; CMC Microsystems","keywords":"Spheroid; Hypoxia (environmental); Microfluidics; Doxorubicin; Cell culture; Biophysics; Fluorescence microscope; Cell; Biomedical engineering; In vitro; Oxygen; Chemistry; Cell biology; Materials science; Biology; Nanotechnology; Medicine; Fluorescence; Chemotherapy; Surgery; Biochemistry; Optics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001993043,0.000182593,0.0002528669,0.0001753344,0.0001270656,0.0001825282,0.0001706023,0.00006454162,0.0000080151],"category_scores_gemma":[0.0001063876,0.0001836531,0.00005835433,0.000348456,0.00003369506,0.000008892185,0.0002703933,0.00008291713,0.00002988747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009410918,"about_ca_system_score_gemma":0.0002140389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004671312,"about_ca_topic_score_gemma":0.00006589019,"domain_scores_codex":[0.9976955,0.0001086856,0.0004412163,0.001058938,0.0002952922,0.0004003804],"domain_scores_gemma":[0.9987233,0.000009750182,0.0001140902,0.0008528967,0.00008631991,0.0002136819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001633485,0.00005041461,0.08998619,0.00003612744,0.0000138896,0.00007545103,0.0003478784,0.0000403527,0.9071893,2.42226e-7,0.0004101993,0.00168657],"study_design_scores_gemma":[0.0006065812,0.0002502922,0.3436844,0.0001715368,0.00001859409,0.0002576861,0.0006095014,0.000002361273,0.6381707,0.000002219707,0.01592392,0.0003022242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818816,0.00647889,0.00004227199,0.00003015808,0.01041025,0.001084956,0.000002365742,0.00002021045,0.00004930405],"genre_scores_gemma":[0.9969187,0.00003703617,0.0001103735,0.00001450314,0.0005697947,0.00006030507,0.000007245459,0.00002710114,0.002254957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2690187,"threshold_uncertainty_score":0.7489156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00926540307004619,"score_gpt":0.2633119969669205,"score_spread":0.2540465938968743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}