{"id":"W2990732605","doi":"10.1371/journal.pcbi.1007495","title":"Determinants of combination GM-CSF immunotherapy and oncolytic virotherapy success identified through in silico treatment personalization","year":2019,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Oncolytic virus; Virotherapy; Immunotherapy; Medicine; Immune system; Combination therapy; Immunology; Oncology; Cancer research; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001278262,0.0001382174,0.0002215741,0.00009632827,0.0000372683,0.00001321196,0.0001183217,0.0001257982,0.00008777487],"category_scores_gemma":[0.00001289858,0.0001291663,0.00004749444,0.00011911,0.0001106268,0.00001140109,0.00002739209,0.00004279768,0.00001028974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000507628,"about_ca_system_score_gemma":0.0001007661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008091366,"about_ca_topic_score_gemma":0.0001372308,"domain_scores_codex":[0.9989314,0.0001860443,0.0002666207,0.0003273633,0.0001169945,0.0001715598],"domain_scores_gemma":[0.9995107,0.00007478282,0.0001159326,0.0001565602,0.0001175006,0.00002452457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001664331,0.0005073159,0.2887695,0.00003099175,0.0001185286,0.000001286918,0.000479952,0.0006286617,0.6992194,0.0005188762,0.000006289603,0.008054818],"study_design_scores_gemma":[0.01363305,0.01800101,0.3376703,0.00007950226,0.0000233207,0.00002192481,0.0002329339,0.02823208,0.5937075,0.007355711,0.0004142224,0.0006284787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978144,0.0009691245,0.0004160648,0.00007871087,0.00006465593,0.0005322085,0.00002538814,0.000006600197,0.00009284366],"genre_scores_gemma":[0.9987227,0.0003791566,0.0002022238,0.0001421883,0.00002886554,0.00005639459,0.0002890526,0.00001893555,0.0001604223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1055119,"threshold_uncertainty_score":0.5267249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02224038202562086,"score_gpt":0.3302926457320427,"score_spread":0.3080522637064219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}