{"id":"W2990741410","doi":"10.1128/jvi.01937-19","title":"Polymorphisms in the Most Oncolytic Reovirus Strain Confer Enhanced Cell Attachment, Transcription, and Single-Step Replication Kinetics","year":2019,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Alberta Cancer Foundation; Canadian Institutes of Health Research; Canada Foundation for Innovation; Canada Research Chairs; Government of Canada","keywords":"Oncolytic virus; Biology; Viral replication; Virology; Virus; Cell culture; Transcription (linguistics); Cancer cell; In vitro; Cancer research; Cell; Molecular biology; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002448481,0.0002803697,0.0002535839,0.0002316913,0.0001335232,0.0004492876,0.0002059799,0.0003420367,0.001225],"category_scores_gemma":[0.0004329991,0.0001720599,0.0004059457,0.0001667156,0.0002440992,0.0001937733,0.000230917,0.0007434853,0.0003928961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003828714,"about_ca_system_score_gemma":0.0002767335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007532929,"about_ca_topic_score_gemma":0.0008824352,"domain_scores_codex":[0.9997761,0.00004452942,0.00003262375,0.00005394498,0.0000514936,0.00004129404],"domain_scores_gemma":[0.9996019,0.0001623462,0.0001004297,0.00006670694,0.0000251611,0.00004352094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009709081,0.00002131401,0.0002097238,0.00001048822,0.00000339867,0.00001371529,0.00001090156,0.00009987957,0.9986883,0.0000754981,0.0000163515,0.0007532511],"study_design_scores_gemma":[0.00001075905,0.0002860943,0.001413813,0.000002410617,0.00001059487,0.0002033666,0.00001330932,0.0009189593,0.9964429,0.00004007486,0.0006507615,0.00000693566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941401,0.0004232436,0.004298925,0.00003899246,0.0000185038,0.0000277402,0.0002787294,0.00008028655,0.0006933547],"genre_scores_gemma":[0.9949028,0.000204911,0.003653693,0.00002203749,0.000005079699,0.00002571618,0.0003566188,0.00007440427,0.0007546661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001225,"threshold_uncertainty_score":0.004097998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02012841227755038,"score_gpt":0.2974336977765288,"score_spread":0.2773052854989784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}