{"id":"W2990744283","doi":"10.1002/bit.27229","title":"The phage display of <i>Bacillus subtilis</i> Lipase A significantly enhances catalytic activity due to altered nanoscale distribution in colloidal solution","year":2019,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bacillus subtilis; Lipase; Nanoscopic scale; Colloid; Chemistry; Distribution (mathematics); Phage display; Enzyme; Catalysis; Biochemistry; Biology; Nanotechnology; Bacteria; Materials science; Organic chemistry; Peptide; Mathematics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000167821,0.0002799704,0.0001829556,0.0001009175,0.00008184522,0.0003525959,0.0001172307,0.0002366948,0.0005780791],"category_scores_gemma":[0.0002226466,0.0001199158,0.0001562704,0.0001142382,0.0001514105,0.0001700114,0.0001716174,0.0003500124,0.0002108593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001716525,"about_ca_system_score_gemma":0.00009355693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003211814,"about_ca_topic_score_gemma":0.0004600851,"domain_scores_codex":[0.9998026,0.00004929248,0.00001600386,0.0000390205,0.00006210224,0.00003098316],"domain_scores_gemma":[0.9998955,0.00003743912,0.00002855098,0.000007697346,0.00001533932,0.00001540945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001322467,0.000003532165,0.00002400235,0.000007351925,9.289969e-7,0.000004180349,0.000002794484,0.00001210898,0.9997452,0.000007329873,0.000003946454,0.000175319],"study_design_scores_gemma":[0.000001813478,0.00009163209,0.0005152678,0.000001171962,0.000003406809,0.00003311887,0.000003949831,0.0001936729,0.9989426,0.000004516246,0.0002071407,0.000001730915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958068,0.000396984,0.002896845,0.00004118403,0.000009721086,0.0000103966,0.00004734172,0.00004397509,0.0007467004],"genre_scores_gemma":[0.996405,0.0002877509,0.002420026,0.00003668334,0.000005326993,0.00001124578,0.0000839225,0.0000226668,0.0007273558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005780791,"threshold_uncertainty_score":0.001933873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00869720894223354,"score_gpt":0.2471591972793334,"score_spread":0.2384619883370999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}