{"id":"W2990770944","doi":"10.1073/pnas.1910590116","title":"Sleep–wake-driven and circadian contributions to daily rhythms in gene expression and chromatin accessibility in the murine cortex","year":2019,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Circadian rhythm; Biology; Wakefulness; Chromatin; Circadian clock; Neuroscience; Enhancer; Regulation of gene expression; CLOCK; Gene expression; Transcription factor; Cell biology; Genetics; Gene; Electroencephalography","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001029836,0.0002322181,0.0001473489,0.0003475109,0.0000660621,0.0001674834,0.0001356378,0.0001218566,0.0002873865],"category_scores_gemma":[0.0001286731,0.0002229571,0.0002572038,0.00009850548,0.0002368549,0.0001288634,0.0001723826,0.0002140438,0.00006573758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000258952,"about_ca_system_score_gemma":0.0002346373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001987231,"about_ca_topic_score_gemma":0.002836904,"domain_scores_codex":[0.9999473,0.000004327509,0.000003477529,0.00001820645,0.00001405546,0.00001257321],"domain_scores_gemma":[0.9998829,0.00001326383,0.00005066767,0.00001234405,0.00001169092,0.00002913496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009721236,0.00001023577,0.001560198,0.00001151622,0.000006009147,0.00001072655,0.00001413306,0.0005483831,0.9964534,0.00008560228,0.00000775973,0.00119478],"study_design_scores_gemma":[0.00003839577,0.0005837386,0.2714933,0.00001248045,0.0000546567,0.0001756731,0.00005001004,0.02388203,0.7023163,0.0005597828,0.000807684,0.0000260129],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968845,0.0002904217,0.002522001,0.000009993511,0.000001941886,0.000003476824,0.0001407229,0.00002107362,0.0001258569],"genre_scores_gemma":[0.9971425,0.0002617891,0.001874295,0.000009609578,0.000002543654,0.00001808705,0.0002027718,0.00001475365,0.0004737356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001987231,"threshold_uncertainty_score":0.003951311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0280149266530023,"score_gpt":0.3088121450198914,"score_spread":0.2807972183668891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}