{"id":"W2990777042","doi":"10.1093/annonc/mdz416.023","title":"KEYNOTE-756: A randomized, double-blind, phase III study of pembrolizumab or placebo with neoadjuvant chemotherapy and adjuvant endocrine therapy for high-risk, early-stage, ER+/HER2−breast cancer","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Oncology; Pembrolizumab; Breast cancer; Internal medicine; Chemotherapy; Adjuvant chemotherapy; Adjuvant; Stage (stratigraphy); Placebo; Cancer; Immunotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001860512,0.002378197,0.003252119,0.0006746143,0.0006685698,0.001250029,0.00146056,0.002095063,0.01112319],"category_scores_gemma":[0.001480277,0.001068884,0.001562768,0.0005144937,0.00166972,0.001331559,0.0004146459,0.003977348,0.001755255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008444299,"about_ca_system_score_gemma":0.001728179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001581405,"about_ca_topic_score_gemma":0.003631023,"domain_scores_codex":[0.9994444,0.0002815248,0.00003223553,0.00009942394,0.00003684613,0.0001055395],"domain_scores_gemma":[0.9993001,0.0001852524,0.0001258815,0.00006103066,0.00003644363,0.000291251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9812045,0.007870724,0.0001582121,0.0004050621,0.000461531,0.00001659635,0.0000244015,0.0001917879,0.002536971,0.0001107178,0.0006039035,0.006415646],"study_design_scores_gemma":[0.9711104,0.02766614,0.0003348861,0.00001115338,0.0001769585,0.000008251405,0.00000987937,0.0001292039,0.0002498751,0.00005095627,0.0002446235,0.000007671539],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735634,0.00485553,0.001582747,0.000983145,0.001406509,0.009636682,0.00288595,0.0004499131,0.004636174],"genre_scores_gemma":[0.9683744,0.003903421,0.003419302,0.002168735,0.0007114375,0.01087763,0.001979735,0.00007633524,0.008488996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01112319,"threshold_uncertainty_score":0.03721076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03680605986598538,"score_gpt":0.3687587752554979,"score_spread":0.3319527153895125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}