{"id":"W2990797617","doi":"10.1016/j.celrep.2019.10.065","title":"The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; Michael Smith Health Research BC; McGill University; University of British Columbia","funders":"Canadian Institutes of Health Research; National Institutes of Health; BC Epilepsy Society; CURE Childhood Cancer","keywords":"Palmitoylation; Inhibitory postsynaptic potential; Excitatory postsynaptic potential; GTPase; Synapse; Cell biology; Dendrite (mathematics); Postsynaptic potential; Dendritic spine; Biology; Neuroscience; Excitatory synapse; Loss function; Hippocampal formation; Genetics; Phenotype; Gene; Cysteine; Biochemistry; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007371552,0.0004280405,0.0002069232,0.0004008884,0.0003131566,0.0002857445,0.0002742436,0.0002901033,0.001531072],"category_scores_gemma":[0.000161668,0.000130855,0.0001860109,0.0002065871,0.0003239021,0.00009457014,0.0004035054,0.0002867554,0.0006427272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003769928,"about_ca_system_score_gemma":0.0003003408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001617965,"about_ca_topic_score_gemma":0.001969917,"domain_scores_codex":[0.9999069,0.00001181732,0.00001461293,0.00001756766,0.00002827549,0.00002084508],"domain_scores_gemma":[0.9998035,0.00004054468,0.00006966923,0.00001726177,0.00001478913,0.00005424443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002187735,0.00002147527,0.001703394,0.00004421831,0.00001028947,0.001465908,0.00002525709,0.0002532271,0.9919828,0.0004675623,0.0001104414,0.003696696],"study_design_scores_gemma":[0.00007970919,0.0001286044,0.05409745,0.00002575431,0.0000376886,0.003771152,0.00008684782,0.002417275,0.9300474,0.0003124514,0.008977595,0.00001809866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939486,0.0007782566,0.00272462,0.0001121109,0.00002716879,0.00001569826,0.0008295588,0.0001453286,0.001418815],"genre_scores_gemma":[0.9958312,0.0003523548,0.001376249,0.00001876067,0.000006672282,0.00001182639,0.0006997648,0.00002493655,0.001678204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001617965,"threshold_uncertainty_score":0.005121946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02891030607708127,"score_gpt":0.3038711601854635,"score_spread":0.2749608541083822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}