{"id":"W2990816080","doi":"10.1152/ajpgi.00011.2019","title":"Impairment of electroneutral Na<sup>+</sup>transport and associated downregulation of NHE3 contributes to the development of diarrhea following in vivo challenge with<i>Brachyspira</i>spp.","year":2019,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Veterinary medicine and infectious diseases","field":"Veterinary","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Livestock and Meat Agency","keywords":"Downregulation and upregulation; Sodium–hydrogen antiporter; Molecular biology; Chemistry; Diarrhea; Ussing chamber; In vivo; Messenger RNA; Biology; Microbiology; Sodium; In vitro; Biochemistry; Internal medicine; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001827854,0.0003003877,0.0002104805,0.0001313815,0.0001233554,0.000236442,0.0001327529,0.0003424013,0.00080098],"category_scores_gemma":[0.0001216372,0.0001947002,0.0003073698,0.00007402102,0.0002549862,0.0002124834,0.0001663568,0.000560246,0.000187178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001936939,"about_ca_system_score_gemma":0.0001838652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000755008,"about_ca_topic_score_gemma":0.001079007,"domain_scores_codex":[0.9998816,0.00001888432,0.00001294943,0.00002545311,0.00002067743,0.0000404565],"domain_scores_gemma":[0.9998583,0.00001972717,0.00005437135,0.00001244685,0.00001595569,0.0000391973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001594404,0.00001473956,0.0006811218,0.00002313634,0.000002697139,0.00003920288,0.00001534159,0.000009633134,0.9988303,0.000008408854,0.000009190879,0.0002068898],"study_design_scores_gemma":[0.00002839968,0.002500881,0.1874568,0.0000195255,0.00004446151,0.0007125188,0.0002680421,0.0008110646,0.8069913,0.0000750121,0.001079855,0.00001206079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982988,0.0002678305,0.000588318,0.00005773666,0.000009052962,0.00001691038,0.0001821931,0.0000242932,0.0005548635],"genre_scores_gemma":[0.9978245,0.0002531428,0.0006902338,0.00006312018,0.00000719121,0.00002190174,0.0002568738,0.00000687023,0.000876185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00080098,"threshold_uncertainty_score":0.002679527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112670918741425,"score_gpt":0.2445618798759971,"score_spread":0.2334351706885829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}