{"id":"W2990816080","doi":"10.1152/ajpgi.00011.2019","title":"Impairment of electroneutral Na<sup>+</sup>transport and associated downregulation of NHE3 contributes to the development of diarrhea following in vivo challenge with<i>Brachyspira</i>spp.","year":2019,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Veterinary medicine and infectious diseases","field":"Veterinary","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Livestock and Meat Agency","keywords":"Downregulation and upregulation; Sodium–hydrogen antiporter; Molecular biology; Chemistry; Diarrhea; Ussing chamber; In vivo; Messenger RNA; Biology; Microbiology; Sodium; In vitro; Biochemistry; Internal medicine; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003534438,0.0002285471,0.0009399402,0.0001848395,0.00004658126,0.000001952856,0.000160079,0.00003463364,0.00003479552],"category_scores_gemma":[0.00004393585,0.000152135,0.0001291581,0.0002388433,0.000387812,0.0001109297,0.00006043512,0.0002223393,7.909475e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004440646,"about_ca_system_score_gemma":0.0001420412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001611646,"about_ca_topic_score_gemma":0.00001849928,"domain_scores_codex":[0.9982634,0.0002655472,0.000749993,0.0002416617,0.0001561032,0.0003233304],"domain_scores_gemma":[0.9984829,0.0003047388,0.0007841776,0.0001462946,0.0001935013,0.00008836219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00420848,0.0005670541,0.08922185,0.0001549498,0.0002991617,0.00001692843,0.00150007,0.0008366748,0.9025112,0.00003830216,0.00001464139,0.0006307171],"study_design_scores_gemma":[0.001640685,0.03221596,0.9609776,0.0005902483,0.00010218,0.0002482975,0.001358122,0.0003072638,0.002313621,0.00008956579,0.00001947412,0.0001369526],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992447,0.0002404087,0.00007799141,0.00009406455,0.00002484927,0.0002720147,0.00001527525,0.000006176023,0.00002454327],"genre_scores_gemma":[0.9991829,0.00003797926,0.0006386688,0.00006929781,0.0000359921,0.00000914205,0.000008022199,0.00001393921,0.000004005359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9001976,"threshold_uncertainty_score":0.6203885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112670918741425,"score_gpt":0.2445618798759971,"score_spread":0.2334351706885829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}