{"id":"W2990824525","doi":"10.1016/j.str.2019.11.005","title":"Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2","year":2019,"lang":"en","type":"article","venue":"Structure","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Engineering and Physical Sciences Research Council; Medical Research Council; Janssen Biotech; Innovative Medicines Initiative; Ontario Ministry of Economic Development and Innovation; UCB; Wellcome Trust; Janssen Pharmaceuticals; Merck KGaA; AbbVie; Merck; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Canada Foundation for Innovation; Novartis; Takeda Pharmaceuticals U.S.A.; Pfizer; Biotechnology and Biological Sciences Research Council; Boehringer Ingelheim","keywords":"Transient receptor potential channel; Biophysics; Chemistry; Ion channel; Transmembrane domain; TRPC1; TRPV; POPC; Binding site; Cell biology; Membrane; Biochemistry; TRPV1; Lipid bilayer; Receptor; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002194593,0.0001071961,0.0001752484,0.00003565885,0.00002500691,0.000003255101,0.00006300474,0.00006308255,0.00004353247],"category_scores_gemma":[0.00007908101,0.0000877143,0.00005178453,0.00005045088,0.00008363448,0.000003854335,0.00006261482,0.00004300992,4.284257e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003353053,"about_ca_system_score_gemma":0.000031859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008291854,"about_ca_topic_score_gemma":0.000008926333,"domain_scores_codex":[0.9994553,0.00002596465,0.0001689172,0.0001760068,0.00008095109,0.00009282954],"domain_scores_gemma":[0.999547,0.00001972091,0.0001076916,0.0001787818,0.0001030393,0.00004377851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001713459,0.000007118917,0.003875906,0.0001987315,0.0001380748,2.509732e-7,0.0002630579,0.003516209,0.9911436,0.00001455671,0.0001296432,0.0005414448],"study_design_scores_gemma":[0.001270612,0.0004774896,0.05887163,0.00008785087,0.0001276981,0.00002209549,0.001599052,0.002258363,0.9327722,0.0008651325,0.001363156,0.0002847664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978155,0.001395713,0.00002902668,0.0000412104,0.0003082887,0.0001437009,0.0001520739,0.000004193922,0.0001102925],"genre_scores_gemma":[0.9993184,0.0000476513,0.0001842505,0.0000436212,0.0001087489,0.000001516712,0.00007148529,0.000009248371,0.0002150439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05837151,"threshold_uncertainty_score":0.3576885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01094468908824069,"score_gpt":0.2932897594091665,"score_spread":0.2823450703209258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}