{"id":"W2990849834","doi":"10.1016/s1470-2045(19)30693-x","title":"Atezolizumab for children and young adults with previously treated solid tumours, non-Hodgkin lymphoma, and Hodgkin lymphoma (iMATRIX): a multicentre phase 1–2 study","year":2019,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":169,"is_retracted":false,"has_abstract":false,"ca_institutions":"Roche (Canada)","funders":"School of Medicine, Stanford University; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino; Penn State Health Children's Hospital; F. Hoffmann-La Roche; Pfizer","keywords":"Atezolizumab; Medicine; Adverse effect; Internal medicine; Clinical trial; Population; Phases of clinical research; Lymphoma; Clinical endpoint; Incidence (geometry); Surgery; Pediatrics; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001839616,0.001029175,0.001692784,0.0002184805,0.0003454267,0.0008403675,0.0005597754,0.001038255,0.001424333],"category_scores_gemma":[0.00183274,0.000533145,0.00185028,0.0004090881,0.0007456754,0.0007447781,0.0005703075,0.001758521,0.000270241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007517586,"about_ca_system_score_gemma":0.0009846461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001409211,"about_ca_topic_score_gemma":0.003938674,"domain_scores_codex":[0.9994271,0.0002647449,0.00004312232,0.0001037321,0.0000502061,0.0001112281],"domain_scores_gemma":[0.9988016,0.0002563362,0.0003810218,0.00008510495,0.00006484948,0.0004110086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7445364,0.01630235,0.1512236,0.002150903,0.009757082,0.0007248293,0.0006423246,0.0007382664,0.007748208,0.000258152,0.003409914,0.06250799],"study_design_scores_gemma":[0.5882654,0.1542895,0.2450779,0.0001703813,0.005178809,0.0008584514,0.0003347152,0.0003606674,0.0007629075,0.000150468,0.00449406,0.00005677733],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951199,0.003298155,0.00008056912,0.0001781147,0.00006856527,0.000346817,0.0005461927,0.000007120279,0.0003545805],"genre_scores_gemma":[0.9925745,0.002830928,0.0005533153,0.0008369022,0.0001852381,0.0007265902,0.00152725,0.000008924125,0.0007563024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001839616,"threshold_uncertainty_score":0.009728968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01209412977024984,"score_gpt":0.3121682710117557,"score_spread":0.3000741412415059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}