{"id":"W2990882070","doi":"10.1038/s41380-019-0588-9","title":"Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence","year":2019,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Holland Bloorview Kids Rehabilitation Hospital; University of Toronto","funders":"National Institute of Biomedical Imaging and Bioengineering; National Natural Science Foundation of China; National Institute on Aging; Agence Nationale de la Recherche; National Institute of Mental Health; Medical Research Council; National Institute for Health and Care Research","keywords":"Epigenome; Epigenetics; DNA methylation; Methylation; Genotype; Genetics; Alcohol dependence; Allele; Biology; Alcohol; Genome-wide association study; Gene; Gene expression; Single-nucleotide polymorphism; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001884661,0.0001375616,0.0001455212,0.00008891283,0.00001825577,0.00001976371,0.0001111809,0.0001428599,0.00002448611],"category_scores_gemma":[0.00003448443,0.0001489969,0.00005536323,0.0001044552,0.00003297647,0.000006940462,0.00005874251,0.00007637397,0.000008557918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007151533,"about_ca_system_score_gemma":0.0000636989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007661051,"about_ca_topic_score_gemma":0.0001895642,"domain_scores_codex":[0.9989165,0.00008436005,0.000277576,0.0003726677,0.0001727427,0.0001761282],"domain_scores_gemma":[0.9993459,0.000009300663,0.0001129885,0.0004163061,0.00006131249,0.00005419581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003506971,0.00002982724,0.3520134,0.00002586082,0.00001421241,8.472888e-7,0.00001276174,0.001425268,0.6452235,0.0002501303,0.000003230667,0.0009659],"study_design_scores_gemma":[0.0006840788,0.0001735743,0.602684,0.00002595167,0.00001401279,0.000003603523,0.00001745568,0.000328566,0.3943218,0.001399508,0.0001733063,0.0001741469],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904893,0.00451912,0.003970197,0.00005923842,0.0002349293,0.0003006899,0.000006748174,0.000004929962,0.0004148474],"genre_scores_gemma":[0.9950888,0.0002766761,0.004327529,0.00007577314,0.00003189533,0.000005300644,0.00004534311,0.00002123481,0.0001274835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2509017,"threshold_uncertainty_score":0.6075916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008574822984294546,"score_gpt":0.2414957526352028,"score_spread":0.2329209296509082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}