{"id":"W2990892635","doi":"10.1186/s12985-019-1249-y","title":"Histone deacetylase 1 interacts with HIV-1 Integrase and modulates viral replication","year":2019,"lang":"en","type":"article","venue":"Virology Journal","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Integrase; Biology; Virology; Viral replication; Molecular biology; Immunoprecipitation; Infectivity; Integrase inhibitor; Cell culture; Virus; Human immunodeficiency virus (HIV); Genetics; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001399057,0.000331448,0.000248174,0.0001913432,0.0001849852,0.0004565533,0.0002554369,0.0002579471,0.001713386],"category_scores_gemma":[0.0001428269,0.0001421206,0.000344398,0.0001755265,0.0002058731,0.000201002,0.0002034735,0.0004259859,0.0005854043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000619642,"about_ca_system_score_gemma":0.0001580302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006818163,"about_ca_topic_score_gemma":0.001206065,"domain_scores_codex":[0.9998684,0.00001021135,0.000007747836,0.00004247199,0.0000409986,0.00003011399],"domain_scores_gemma":[0.9999356,0.000009034564,0.00001943548,0.00000572267,0.000009186128,0.00002100042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001627847,0.00002828239,0.002192463,0.00008838666,0.00002271512,0.0000564475,0.00001718792,0.00006483488,0.9941885,0.00009572648,0.0001555063,0.002927024],"study_design_scores_gemma":[0.00004429719,0.0002688954,0.05180961,0.00002321712,0.00008506412,0.0005114616,0.00006644599,0.003012857,0.9372389,0.0001459336,0.006778767,0.00001457941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844195,0.008735381,0.002881851,0.0002527146,0.00007220156,0.00002790233,0.0007594851,0.0001117521,0.002739266],"genre_scores_gemma":[0.9922805,0.002506124,0.001675571,0.0001038075,0.00002797454,0.00001533971,0.001054022,0.0000250574,0.002311583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001713386,"threshold_uncertainty_score":0.005731881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005260312223834165,"score_gpt":0.2681331501405341,"score_spread":0.2628728379166999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}