{"id":"W2990934204","doi":"10.1016/j.cbpa.2019.09.005","title":"Drugging the gut microbiota: toward rational modulation of bacterial composition in the gut","year":2019,"lang":"en","type":"review","venue":"Current Opinion in Chemical Biology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Glycomics Network; Kenneth Rainin Foundation","keywords":"Gut flora; Druggability; Biology; Gastrointestinal tract; Probiotic; Gut microbiome; Gut–brain axis; Drug discovery; Gut bacteria; Human gastrointestinal tract; Computational biology; Bioinformatics; Immunology; Bacteria; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007109484,0.001095554,0.001886898,0.0009569242,0.0002102643,0.001366338,0.001125398,0.001779606,0.003084221],"category_scores_gemma":[0.0006937542,0.000247748,0.0004652663,0.001217536,0.0007615337,0.001340296,0.0008350441,0.003227101,0.002347094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007443896,"about_ca_system_score_gemma":0.0009361539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006794267,"about_ca_topic_score_gemma":0.00161682,"domain_scores_codex":[0.9998108,0.00003060892,0.0000147695,0.00004308633,0.00007059169,0.0000302136],"domain_scores_gemma":[0.9996891,0.0001307249,0.0000393172,0.0000108551,0.00007630318,0.00005373071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001906898,0.0001205303,0.0001692695,0.01287201,0.00011605,0.0001592998,0.00002728627,0.0006119286,0.006842365,0.008723541,0.04368785,0.9264792],"study_design_scores_gemma":[0.000057657,0.0001777177,0.0005339451,0.001769493,0.000147948,0.0004753968,0.00004867329,0.0003188152,0.001836535,0.004751475,0.9898493,0.00003306179],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001437175,0.9971364,0.0005419839,0.0008314799,0.000606477,0.00000517903,0.00002586733,0.00001805645,0.0006908664],"genre_scores_gemma":[0.0009637267,0.997112,0.000391644,0.0005651335,0.000320833,0.000008802683,0.00003302818,0.000002833202,0.000601924],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003084221,"threshold_uncertainty_score":0.01031774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1084155869197804,"score_gpt":0.4091456853069269,"score_spread":0.3007300983871465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}