{"id":"W2990980893","doi":"10.1146/annurev-cancerbio-030419-033525","title":"Reactivation of Endogenous Retroelements in Cancer Development and Therapy","year":2019,"lang":"en","type":"article","venue":"Annual Review of Cancer Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Epigenetics; Biology; Carcinogenesis; Retrotransposon; Genetics; Cancer; Germline; Genome; Gene; Transposable element","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002487239,0.000073284,0.0002162639,0.0000301837,0.000007147664,6.548614e-7,0.00006115084,0.00006553256,0.00003417113],"category_scores_gemma":[0.00003022371,0.00006041358,0.0000245527,0.00006633713,0.00002784764,0.00000291194,0.00003090475,0.00003044457,4.318368e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001234679,"about_ca_system_score_gemma":0.0001086967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002257572,"about_ca_topic_score_gemma":0.00007320776,"domain_scores_codex":[0.9993179,0.00005787012,0.0003117812,0.0001636173,0.00005263501,0.00009615505],"domain_scores_gemma":[0.9995392,0.00001086694,0.0002054964,0.0001153951,0.0001129895,0.00001603074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003365777,0.00002232769,0.1012584,0.000417944,0.00003071642,5.016091e-8,0.00006734108,0.000001942285,0.6665968,0.00003794369,0.00001338185,0.2315195],"study_design_scores_gemma":[0.0004167482,0.0002983161,0.03227842,0.0005655353,0.000006161083,2.156036e-7,0.00001930649,7.862631e-7,0.8214563,0.00004130337,0.1448312,0.00008577069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6975037,0.3019155,0.0000133845,0.00006125751,0.00005146442,0.0001985148,0.00002064137,6.286406e-7,0.0002349142],"genre_scores_gemma":[0.615034,0.3845709,0.000124907,0.0001565166,0.00001718287,0.0000297483,0.00004178934,0.000003942128,0.00002098664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2314337,"threshold_uncertainty_score":0.2463594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02592781651527412,"score_gpt":0.3419003105546022,"score_spread":0.3159724940393281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}