{"id":"W2990980980","doi":"10.1111/bph.14936","title":"Clinical relevance of St. John's wort drug interactions revisited","year":2019,"lang":"en","type":"review","venue":"British Journal of Pharmacology","topic":"Natural Compound Pharmacology Studies","field":"Agricultural and Biological Sciences","cited_by":172,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Pharmacology; Indinavir; CYP3A4; Pharmacokinetics; Drug interaction; Digoxin; Medicine; Ranolazine; Pregnane X receptor; Drug; Alprazolam; Cytochrome P450; Chemistry; Internal medicine; Nuclear receptor; Human immunodeficiency virus (HIV); Anxiety","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006525792,0.0005592646,0.001196278,0.001796731,0.0002234992,0.001029782,0.0005328805,0.001225327,0.003067465],"category_scores_gemma":[0.0009167722,0.0002077951,0.0005048693,0.001547417,0.0006297127,0.00131187,0.0004826484,0.001833113,0.001049651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006330455,"about_ca_system_score_gemma":0.0009767072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008554457,"about_ca_topic_score_gemma":0.002114261,"domain_scores_codex":[0.9996849,0.00007245639,0.0000534757,0.00005709351,0.0001100136,0.00002208476],"domain_scores_gemma":[0.9993237,0.000392541,0.00008908874,0.00001237617,0.0001478906,0.00003447889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008680962,0.00004746842,0.0002199091,0.01087778,0.00005936286,0.0004165189,0.00008685402,0.0001418247,0.0009537014,0.003630929,0.01608291,0.9673959],"study_design_scores_gemma":[0.00003492217,0.000220805,0.001991845,0.006613822,0.0001720637,0.00722408,0.0001847272,0.0001168666,0.0006859477,0.003053861,0.9796765,0.00002451586],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001230521,0.9986033,0.00005125492,0.0005042452,0.0001261676,0.000001392299,0.000004999176,0.00000344555,0.0005821274],"genre_scores_gemma":[0.001729808,0.9969374,0.00009515182,0.0004324979,0.0003072341,0.000002782718,0.0000114891,0.000001127509,0.0004825241],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003067465,"threshold_uncertainty_score":0.01026171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08549347228335684,"score_gpt":0.4183079306823161,"score_spread":0.3328144583989592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}