{"id":"W2990991051","doi":"10.2174/1567205016666191121142558","title":"Genome-wide Network-assisted Association and Enrichment Study of Amyloid Imaging Phenotype in Alzheimer’s Disease","year":2019,"lang":"en","type":"article","venue":"Current Alzheimer Research","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; Fundamental Research Funds for the Central Universities; National Institutes of Health; Servier; National Natural Science Foundation of China; Eisai; H. Lundbeck A/S; U.S. National Library of Medicine; IXICO; Natural Science Foundation of Heilongjiang Province; Harbin Engineering University; Genentech; Northern California Institute for Research and Education; Biogen; Ministry of Education, India; BioClinica; Pfizer; Novartis Pharmaceuticals Corporation; Eli Lilly and Company; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; University of Pennsylvania; University of Southern California; Changzhou Institute of Technology; Bristol-Myers Squibb","keywords":"Phenotype; Computational biology; Disease; Genetic association; Biology; Alzheimer's disease; Genetics; Gene; PSEN1; Genome-wide association study; Bioinformatics; Single-nucleotide polymorphism; Amyloid precursor protein; Genotype; Medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0014176,0.000162056,0.0002220653,0.0001263694,0.00008610424,0.00005047747,0.0002453327,0.0000698209,0.00003098207],"category_scores_gemma":[0.00005264728,0.0001571636,0.00005137509,0.000279156,0.00005055217,0.00001152626,0.000429042,0.0003175059,0.0000246991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004182281,"about_ca_system_score_gemma":0.0001111008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003451236,"about_ca_topic_score_gemma":0.0000435168,"domain_scores_codex":[0.9979871,0.0002447042,0.000410481,0.0003773795,0.0004424249,0.0005379417],"domain_scores_gemma":[0.9990034,0.00007540764,0.0001522685,0.0004170684,0.0001942629,0.0001576454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001997607,0.0005441052,0.9673712,0.0000323458,0.0003519719,0.000001984752,0.0004017881,0.0005234541,0.001640566,0.00004098837,0.001623019,0.02726885],"study_design_scores_gemma":[0.00251645,0.0003809994,0.9756972,0.00006214819,0.0001922594,6.790761e-7,0.0006771336,0.002883569,0.0002118275,0.0002691747,0.01671937,0.0003892208],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.954833,0.04312805,0.00002832481,0.0001079432,0.0002701553,0.001106477,0.000009343329,0.000006097018,0.0005106354],"genre_scores_gemma":[0.9989231,0.0006127788,0.00004248002,0.00002391336,0.0001673323,0.00005186188,0.0001141292,0.00002075224,0.00004371817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04409006,"threshold_uncertainty_score":0.6408946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0481418989294566,"score_gpt":0.3412801032484116,"score_spread":0.293138204318955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}