{"id":"W2990991051","doi":"10.2174/1567205016666191121142558","title":"Genome-wide Network-assisted Association and Enrichment Study of Amyloid Imaging Phenotype in Alzheimer’s Disease","year":2019,"lang":"en","type":"article","venue":"Current Alzheimer Research","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; Fundamental Research Funds for the Central Universities; National Institutes of Health; Servier; National Natural Science Foundation of China; Eisai; H. Lundbeck A/S; U.S. National Library of Medicine; IXICO; Natural Science Foundation of Heilongjiang Province; Harbin Engineering University; Genentech; Northern California Institute for Research and Education; Biogen; Ministry of Education, India; BioClinica; Pfizer; Novartis Pharmaceuticals Corporation; Eli Lilly and Company; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; University of Pennsylvania; University of Southern California; Changzhou Institute of Technology; Bristol-Myers Squibb","keywords":"Phenotype; Computational biology; Disease; Genetic association; Biology; Alzheimer's disease; Genetics; Gene; PSEN1; Genome-wide association study; Bioinformatics; Single-nucleotide polymorphism; Amyloid precursor protein; Genotype; Medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009426182,0.000359114,0.0004743377,0.002009325,0.0003187873,0.0004218472,0.0004304387,0.0002817785,0.001229915],"category_scores_gemma":[0.002044228,0.0001446177,0.0007938024,0.001446227,0.0002023607,0.0002631467,0.0004980939,0.000299441,0.000133561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003701056,"about_ca_system_score_gemma":0.0004156346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002324715,"about_ca_topic_score_gemma":0.003107534,"domain_scores_codex":[0.9995719,0.0001678442,0.0000207905,0.0001507402,0.0000416786,0.00004707057],"domain_scores_gemma":[0.9986702,0.0007184173,0.0002508442,0.0001115639,0.0001383314,0.0001106372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001349518,0.000221641,0.861919,0.0003681763,0.003108132,0.0006138355,0.0002406025,0.03996003,0.04164893,0.001747954,0.00128504,0.04753707],"study_design_scores_gemma":[0.00005466793,0.000248474,0.7475643,0.000023288,0.001118225,0.0006386439,0.0001203978,0.2411622,0.004706089,0.003008597,0.001320508,0.00003454709],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769874,0.0005246534,0.02042743,0.00009768753,0.000009639924,0.00003710677,0.001318819,0.0001606207,0.0004366835],"genre_scores_gemma":[0.9892122,0.0001134083,0.009036802,0.0000179389,0.000008192384,0.00004966566,0.001337567,0.0000131511,0.0002110538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002324715,"threshold_uncertainty_score":0.004985094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0481418989294566,"score_gpt":0.3412801032484116,"score_spread":0.293138204318955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}