{"id":"W2991045289","doi":"10.1136/jmedgenet-2019-106283","title":"Genetic variability and potential effects on clinical trial outcomes: perspectives in Parkinson’s disease","year":2019,"lang":"en","type":"article","venue":"Journal of Medical Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Medical Research Council; National Institutes of Health; Rosetrees Trust","keywords":"Clinical trial; Medicine; Parkinson's disease; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1802731,0.0006574512,0.00193064,0.001068677,0.0005708272,0.003291437,0.001793001,0.003079345,0.002980898],"category_scores_gemma":[0.4425306,0.0005179326,0.003122531,0.001648394,0.004804944,0.002535491,0.001582847,0.003507834,0.0002298126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00170812,"about_ca_system_score_gemma":0.002257985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001909276,"about_ca_topic_score_gemma":0.001397759,"domain_scores_codex":[0.7814902,0.2024793,0.003848706,0.006332932,0.004929642,0.0009192041],"domain_scores_gemma":[0.3210021,0.6324832,0.02375653,0.01592322,0.005139656,0.001695386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01224914,0.0003950535,0.5502051,0.003255694,0.02075535,0.001392173,0.002760644,0.08413561,0.001389497,0.07009218,0.00702005,0.2463495],"study_design_scores_gemma":[0.002818778,0.00581449,0.3402993,0.002553689,0.01034499,0.00226801,0.001453198,0.1659186,0.002047856,0.4488927,0.01722838,0.000360102],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5889724,0.09623029,0.2059536,0.09036396,0.00174172,0.0005771982,0.001717701,0.0004426806,0.01400044],"genre_scores_gemma":[0.9767438,0.003464786,0.01476537,0.003291079,0.000706083,0.0002439249,0.0002081005,0.00006764963,0.0005092364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1802731,"threshold_uncertainty_score":0.9533869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02132221289439754,"score_gpt":0.3518127162355322,"score_spread":0.3304905033411346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}