{"id":"W2991045289","doi":"10.1136/jmedgenet-2019-106283","title":"Genetic variability and potential effects on clinical trial outcomes: perspectives in Parkinson’s disease","year":2019,"lang":"en","type":"article","venue":"Journal of Medical Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Medical Research Council; National Institutes of Health; Rosetrees Trust","keywords":"Clinical trial; Medicine; Parkinson's disease; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002909019,0.0001576275,0.0004692206,0.00006895448,0.00002662413,0.00001421636,0.0002792756,0.0003769606,0.00005363175],"category_scores_gemma":[0.004635843,0.0001217136,0.0002258462,0.00005849434,0.0001188843,0.000002128576,0.0001230594,0.0003941778,0.000006557981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002817437,"about_ca_system_score_gemma":0.0003453304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002824684,"about_ca_topic_score_gemma":0.000003437199,"domain_scores_codex":[0.9971611,0.0008705938,0.0008751163,0.0003285691,0.0005151394,0.0002494644],"domain_scores_gemma":[0.9984625,0.0003975595,0.0003362712,0.000284817,0.000104861,0.0004140008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002459151,0.0004844778,0.9850965,0.00002230715,0.0001083043,0.0000424023,0.00004623103,0.0003334228,0.0001477968,0.00002138449,0.0005593682,0.01067868],"study_design_scores_gemma":[0.01690665,0.002379753,0.9757227,0.00002994674,0.00005290185,0.00001692674,0.00007958024,0.0005826261,0.00001619659,0.000442566,0.003638313,0.000131861],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943811,0.001086166,0.001186154,0.00190831,0.001088036,0.0002974511,0.00000359651,0.000002019266,0.00004715822],"genre_scores_gemma":[0.9933853,0.003322647,0.001527594,0.0007113275,0.0009789482,0.000005252013,0.000002609818,0.00001390443,0.00005243215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0144475,"threshold_uncertainty_score":0.5549872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02132221289439754,"score_gpt":0.3518127162355322,"score_spread":0.3304905033411346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}