{"id":"W2991057190","doi":"10.1182/blood.v130.suppl_1.3124.3124","title":"Daratumumab in Combination with Lenalidomide Plus Dexamethasone Results in Persistent Natural Killer (NK) Cells with a Distinct Phenotype and Expansion of Effector Memory T-Cells in Pollux, a Phase 3 Randomized Study","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Daratumumab; CD38; Lenalidomide; Immunophenotyping; Antibody-dependent cell-mediated cytotoxicity; Immune system; Immunology; Antibody; Cytotoxic T cell; Biology; Cancer research; Monoclonal antibody; Multiple myeloma; Flow cytometry; CD34; Stem cell; In vitro; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001780006,0.001083185,0.00186593,0.0002821217,0.0003184768,0.00133344,0.0007396826,0.0007922073,0.003411002],"category_scores_gemma":[0.0009956183,0.0004849531,0.001860655,0.0003032612,0.0006964871,0.0006560389,0.0002757546,0.001645654,0.0005774907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008996294,"about_ca_system_score_gemma":0.0009067881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006184127,"about_ca_topic_score_gemma":0.001928635,"domain_scores_codex":[0.9992443,0.0003780246,0.00005532609,0.0001329843,0.0000973631,0.00009207302],"domain_scores_gemma":[0.9995042,0.0001099351,0.0001200071,0.00006429828,0.00003611822,0.0001654432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8970954,0.01245302,0.004343848,0.0009766872,0.003685854,0.0001502406,0.0001022421,0.0005468414,0.01696214,0.0002150185,0.002268714,0.0612001],"study_design_scores_gemma":[0.8061964,0.1762401,0.01032397,0.0000622194,0.001837196,0.0002907983,0.00005507195,0.0006048421,0.001924224,0.0001738593,0.002258658,0.00003280621],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893907,0.005512807,0.0006008777,0.0004871651,0.0003154777,0.001446393,0.0006244267,0.00009092397,0.001531227],"genre_scores_gemma":[0.9918926,0.00197945,0.001211283,0.000853478,0.0002381281,0.001014375,0.0007888332,0.00002068479,0.00200129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003411002,"threshold_uncertainty_score":0.01141089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01838477669557106,"score_gpt":0.29785285607191,"score_spread":0.279468079376339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}