{"id":"W2991061300","doi":"10.3747/co.26.5719","title":"Current and Emerging Biomarkers in Metastatic Colorectal Cancer","year":2019,"lang":"en","type":"review","venue":"Current Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ipsen; Amgen","keywords":"Medicine; Colorectal cancer; Microsatellite instability; Companion diagnostic; Clinical significance; Oncology; Cancer; DNA mismatch repair; Targeted therapy; Biomarker; Disease; Personalized medicine; Mutation; Chromosome instability; Internal medicine; Bioinformatics; Cancer research; Gene; Microsatellite; Biology; Genetics; Chromosome; Allele","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002031945,0.0005019382,0.002953073,0.0004329678,0.00005478902,0.00001187902,0.00009449691,0.0001374376,0.0001370294],"category_scores_gemma":[0.00006960184,0.0003580782,0.0003276569,0.0004194311,0.0001503699,0.00003714325,0.0001801417,0.0005796056,0.00003466437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001427974,"about_ca_system_score_gemma":0.001110334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006606035,"about_ca_topic_score_gemma":0.0003706355,"domain_scores_codex":[0.997874,0.000191889,0.0006511815,0.0006446548,0.0001848412,0.0004533881],"domain_scores_gemma":[0.9990344,0.0002777212,0.0003176461,0.0001685649,0.00006299176,0.0001386518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009103922,0.0003951984,0.00280088,0.02007026,0.0008866184,0.00004793481,0.000221437,7.180139e-8,1.364179e-7,0.00001677075,0.001264095,0.9742056],"study_design_scores_gemma":[0.001650322,0.000551705,0.001066275,0.01179374,0.003806764,0.00007642193,0.00006683939,0.00001631024,1.645515e-7,0.00000980682,0.9806747,0.0002868904],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001380034,0.9919412,0.000001421355,0.0001109009,0.003760178,0.002066748,0.00009963907,0.00002774014,0.0006121632],"genre_scores_gemma":[0.0001589436,0.9982668,0.00002580528,0.00001154363,0.0001935612,0.001135518,0.0001258832,0.0000415412,0.00004039528],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9794106,"threshold_uncertainty_score":0.9998871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2200317079574081,"score_gpt":0.5041194988588992,"score_spread":0.2840877909014911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}