{"id":"W2991066530","doi":"10.1073/pnas.1901639116","title":"Critical role for TRIM28 and HP1β/γ in the epigenetic control of T cell metabolic reprograming and effector differentiation","year":2019,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Agence Nationale de la Recherche","keywords":"Biology; Gene silencing; Epigenetics; Effector; Chromatin immunoprecipitation; Cell biology; Cellular differentiation; Chromatin; Histone H3; Heterochromatin protein 1; Heterochromatin; Regulation of gene expression; Histone; Cancer research; Genetics; Gene expression; Gene; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001489021,0.0002240514,0.0001813935,0.0001599429,0.0002208471,0.0002790973,0.0002878203,0.000301365,0.001578146],"category_scores_gemma":[0.0001409544,0.0001670271,0.0002179526,0.00005825559,0.0002971208,0.000265601,0.0004221655,0.0004842807,0.0004564353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002937664,"about_ca_system_score_gemma":0.0002539144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000542618,"about_ca_topic_score_gemma":0.0008327545,"domain_scores_codex":[0.9998786,0.00001302605,0.000008555288,0.00004000721,0.00002961368,0.00003011025],"domain_scores_gemma":[0.9998668,0.00001094763,0.00003581246,0.00002060132,0.00001372747,0.00005207457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001078282,0.000008901947,0.0005313256,0.00002158941,0.000005016518,0.00006841381,0.000021531,0.00008943418,0.997135,0.0001695989,0.00003302879,0.001808265],"study_design_scores_gemma":[0.00003612521,0.0002127363,0.04049981,0.0000104762,0.00002446149,0.0006814266,0.000120078,0.001939985,0.9531078,0.0003560774,0.003001381,0.000009598654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898775,0.002956214,0.004621976,0.0001391846,0.00002999034,0.00002309961,0.0001987114,0.0001229881,0.0020304],"genre_scores_gemma":[0.9953157,0.0005046313,0.001697699,0.00006300743,0.00001100249,0.0000188615,0.0002273908,0.00001980315,0.002141857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001578146,"threshold_uncertainty_score":0.005279422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0140953995805539,"score_gpt":0.274239013652924,"score_spread":0.2601436140723701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}