{"id":"W2991111086","doi":"10.1016/j.jalz.2019.09.074","title":"Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD","year":2019,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Health and Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Alzheimer's Australia; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Biogen; Edith Cowan University; Eli Lilly and Company; Bristol-Myers Squibb; F. Hoffmann-La Roche; Alzheimer's Drug Discovery Foundation; National Institute on Aging; Alzheimer's Association; Science and Industry Endowment Fund; AbbVie","keywords":"Cognitive decline; Dementia; Clinical Dementia Rating; Cognition; Neuroimaging; Hazard ratio; Disease; Medicine; Alzheimer's Disease Neuroimaging Initiative; Psychology; Proportional hazards model; Alzheimer's disease; Effects of sleep deprivation on cognitive performance; Gerontology; Internal medicine; Psychiatry; Confidence interval","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03242529,0.0005154118,0.0009568768,0.0009793508,0.0001947517,0.001124584,0.0009350499,0.0005846697,0.000921885],"category_scores_gemma":[0.04784423,0.0002446794,0.002404008,0.001280653,0.001310071,0.0008421081,0.0006979519,0.001294126,0.00006231722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004145474,"about_ca_system_score_gemma":0.001016546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00186195,"about_ca_topic_score_gemma":0.002309603,"domain_scores_codex":[0.9876037,0.00937382,0.0008610195,0.0009475158,0.001105884,0.0001081529],"domain_scores_gemma":[0.9066619,0.07545484,0.01305431,0.002676796,0.001669808,0.0004824361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008157344,0.0001726745,0.8299043,0.01048053,0.04088663,0.0001515995,0.0004565696,0.002745872,0.0007721432,0.002235923,0.002084454,0.1019521],"study_design_scores_gemma":[0.001139842,0.003337109,0.9243623,0.004954384,0.04007528,0.0006564652,0.0002831066,0.004981049,0.001799025,0.01090278,0.007405744,0.0001030363],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6576478,0.3134437,0.0112723,0.007372262,0.0006689049,0.0003374799,0.003051423,0.000116263,0.006089969],"genre_scores_gemma":[0.9873237,0.00951245,0.001576203,0.0006434352,0.0003053906,0.0000797597,0.0003871227,0.00000752699,0.000164412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03242529,"threshold_uncertainty_score":0.1714833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1283738510087885,"score_gpt":0.4231063093396362,"score_spread":0.2947324583308477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}