{"id":"W2991111086","doi":"10.1016/j.jalz.2019.09.074","title":"Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD","year":2019,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Health and Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Alzheimer's Australia; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Biogen; Edith Cowan University; Eli Lilly and Company; Bristol-Myers Squibb; F. Hoffmann-La Roche; Alzheimer's Drug Discovery Foundation; National Institute on Aging; Alzheimer's Association; Science and Industry Endowment Fund; AbbVie","keywords":"Cognitive decline; Dementia; Clinical Dementia Rating; Cognition; Neuroimaging; Hazard ratio; Disease; Medicine; Alzheimer's Disease Neuroimaging Initiative; Psychology; Proportional hazards model; Alzheimer's disease; Effects of sleep deprivation on cognitive performance; Gerontology; Internal medicine; Psychiatry; Confidence interval","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001890057,0.0002323108,0.0006308988,0.0002203173,0.00004200478,0.00002041639,0.0001857183,0.0001473153,0.001371466],"category_scores_gemma":[0.0009829294,0.0002062192,0.0002082699,0.0004644793,0.0001914644,0.0001188309,0.000246697,0.0005533507,0.0004834946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008033483,"about_ca_system_score_gemma":0.0002079226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006650088,"about_ca_topic_score_gemma":0.00004425665,"domain_scores_codex":[0.9968079,0.000264622,0.001038992,0.0006416363,0.00073736,0.0005095209],"domain_scores_gemma":[0.9973648,0.001404505,0.0002431206,0.0003311701,0.0004523993,0.0002039653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001302843,0.001480087,0.8858207,0.00002670617,0.002866648,0.00006740171,0.00003099335,0.000001694785,0.0002456885,0.00004041137,0.00007179723,0.108045],"study_design_scores_gemma":[0.005964596,0.002860412,0.9792137,0.0004484264,0.00376796,0.00001306405,0.0001225176,0.0005067397,0.006451927,0.0001183892,0.0003371252,0.0001951956],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843807,0.003461229,0.0001477286,0.0002401989,0.0002808,0.001030893,0.00001024128,0.00003624385,0.01041198],"genre_scores_gemma":[0.9984208,0.0000423013,0.0008063062,0.0004340961,0.0001029483,0.0000498617,0.00004670477,0.00003494052,0.0000620005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1078499,"threshold_uncertainty_score":0.9995414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1283738510087885,"score_gpt":0.4231063093396362,"score_spread":0.2947324583308477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}