{"id":"W2991162290","doi":"10.7554/elife.48118","title":"Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation","year":2019,"lang":"en","type":"article","venue":"eLife","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Neurological Disorders and Stroke; Defense Advanced Research Projects Agency; Boston Children's Hospital; Harvard Medical School","keywords":"Chemistry; Dorsal root ganglion; Calcium channel; T-type calcium channel; Sodium channel; Calcium; Nociceptor; Calcitonin gene-related peptide; Pharmacology; Voltage-dependent calcium channel; Neurogenic inflammation; Extracellular; Biophysics; Calcitonin; Calcium in biology; Sodium; Neuropeptide; Biochemistry; Nociception; Neuroscience; Receptor; Endocrinology; Medicine; Sensory system; Biology; Substance P","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004423123,0.000139488,0.0001526047,0.00005395668,0.00009262255,0.00003373682,0.0001223338,0.0000490219,0.00002036617],"category_scores_gemma":[0.0001339044,0.0001251714,0.00004550146,0.0001202999,0.00005798839,0.0002192657,0.0001303311,0.0001736036,0.0004682614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001195943,"about_ca_system_score_gemma":0.00002245855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000515695,"about_ca_topic_score_gemma":0.000001013334,"domain_scores_codex":[0.998965,0.00004686305,0.0001589165,0.0004088272,0.0001658229,0.0002545815],"domain_scores_gemma":[0.9995473,0.00007680443,0.00009302257,0.0001636949,0.00003157686,0.00008758885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006251132,0.00002580632,0.00003931277,0.0000101792,0.00000204282,0.000004081547,0.0001064181,0.00001513412,0.9986304,0.0004249698,0.0001053497,0.0005737614],"study_design_scores_gemma":[0.0005298345,0.0001528987,0.00660286,0.00000913301,0.000003170598,0.0000100003,0.00002303356,0.0009526131,0.9869891,0.00002529626,0.004559739,0.0001423377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975823,0.000008270577,0.000009286353,0.0002388868,0.0004411707,0.0002607607,0.00001879681,0.00006974922,0.001370806],"genre_scores_gemma":[0.9967107,0.00003900462,0.00001009373,0.002453144,0.0003655241,0.00001001695,0.000003374594,0.00002382217,0.0003843235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01164135,"threshold_uncertainty_score":0.6018709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03162150492145101,"score_gpt":0.2503651582370404,"score_spread":0.2187436533155893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}