{"id":"W2991162290","doi":"10.7554/elife.48118","title":"Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation","year":2019,"lang":"en","type":"article","venue":"eLife","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Neurological Disorders and Stroke; Defense Advanced Research Projects Agency; Boston Children's Hospital; Harvard Medical School","keywords":"Chemistry; Dorsal root ganglion; Calcium channel; T-type calcium channel; Sodium channel; Calcium; Nociceptor; Calcitonin gene-related peptide; Pharmacology; Voltage-dependent calcium channel; Neurogenic inflammation; Extracellular; Biophysics; Calcitonin; Calcium in biology; Sodium; Neuropeptide; Biochemistry; Nociception; Neuroscience; Receptor; Endocrinology; Medicine; Sensory system; Biology; Substance P","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001231305,0.0003359099,0.0002541426,0.0002019636,0.0001279151,0.0001971121,0.0003841578,0.0002693931,0.001189828],"category_scores_gemma":[0.00009432013,0.0001005812,0.0001993256,0.0001336337,0.0001788998,0.0002139981,0.0001829365,0.0003559647,0.0002369093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001637622,"about_ca_system_score_gemma":0.0002686654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002922035,"about_ca_topic_score_gemma":0.0005006038,"domain_scores_codex":[0.9999166,0.000009694234,0.000007112571,0.0000199352,0.00002635186,0.00002029203],"domain_scores_gemma":[0.9999634,0.000003970792,0.000008964573,0.000002379668,0.000007609891,0.00001370758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001373456,0.00004599702,0.00007930453,0.0000643301,0.000009258787,0.00006302253,0.000007633951,0.00007226478,0.9953187,0.0003492832,0.00006313736,0.00378957],"study_design_scores_gemma":[0.0001892,0.001354191,0.001351313,0.00001220502,0.0000471885,0.0004992012,0.000009901195,0.0008264726,0.9880996,0.00009599354,0.007502139,0.00001257352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9692913,0.009094309,0.0136538,0.0002383161,0.0001559831,0.0002033923,0.000269257,0.0001873764,0.006906393],"genre_scores_gemma":[0.9831771,0.004454411,0.006893671,0.0001487539,0.00004198242,0.00009992027,0.0003389254,0.00001955205,0.004825635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001189828,"threshold_uncertainty_score":0.003980398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03162150492145101,"score_gpt":0.2503651582370404,"score_spread":0.2187436533155893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}