{"id":"W2991183309","doi":"10.1007/s11101-019-09644-w","title":"Benzylisoquinoline alkaloid biosynthesis in opium poppy: an update","year":2019,"lang":"en","type":"article","venue":"Phytochemistry Reviews","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Opium Poppy; Thebaine; Benzylisoquinoline; Papaver; Noscapine; Sanguinarine; Codeine; Hydrocodone; Opium; Poppy; Oxycodone; Biology; Opioid; Alkaloid; Pharmacology; Morphine; Genetics; Botany; Gene; Biosynthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0006228269,0.0002644268,0.0007859711,0.00008336706,0.00002615232,0.00002699418,0.0002726607,0.0001295295,0.002993723],"category_scores_gemma":[0.0002042219,0.0002162509,0.0001887837,0.0004248271,0.00004855754,0.0001456787,0.0001030197,0.0004181172,0.001429665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000758443,"about_ca_system_score_gemma":0.00009911831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004242603,"about_ca_topic_score_gemma":0.00001658475,"domain_scores_codex":[0.9980512,0.00008291953,0.0005604292,0.0005396715,0.0002800558,0.0004857119],"domain_scores_gemma":[0.9984935,0.00003596649,0.0001088247,0.001013071,0.00007125176,0.000277376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001623701,0.0005365884,0.02146564,0.002364962,0.00003394329,0.00005351788,0.00005267214,0.000001128132,0.8835278,0.00003243077,0.007574834,0.08419412],"study_design_scores_gemma":[0.001296873,0.0001617852,0.003165563,0.0009464842,0.00004160012,0.0000838638,0.00004367627,0.000192266,0.3056833,0.00006244583,0.6879423,0.0003798278],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9541278,0.01731235,0.00001212932,0.001915677,0.00008878703,0.001357826,0.00002579163,0.00006815128,0.02509145],"genre_scores_gemma":[0.9738253,0.01507696,0.001641785,0.001372433,0.0006387904,0.0001801742,0.0003277337,0.00006714556,0.006869641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6803675,"threshold_uncertainty_score":0.9993479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03022717018064828,"score_gpt":0.338312605052515,"score_spread":0.3080854348718667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}