{"id":"W2991202638","doi":"10.1093/labmed/lmz068","title":"Precision of Fetal DNA Fraction Estimation by Quantitative Polymerase Chain Reaction Quantification of a Differently Methylated Target in Noninvasive Prenatal Testing","year":2019,"lang":"en","type":"article","venue":"Laboratory Medicine","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Genome Alberta; Genome British Columbia; Génome Québec; Genome Canada","keywords":"genomic DNA; Polymerase chain reaction; Restriction enzyme; Biology; DNA methylation; DNA; Molecular biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02081157,0.001206713,0.001181998,0.001792215,0.0005185768,0.002021228,0.001369858,0.001761872,0.0009739974],"category_scores_gemma":[0.0329546,0.0007429902,0.0008771243,0.0009598699,0.002075125,0.0006657261,0.001135672,0.001320934,0.0006818083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000791323,"about_ca_system_score_gemma":0.0007012242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001723492,"about_ca_topic_score_gemma":0.002424173,"domain_scores_codex":[0.9728799,0.01148669,0.001176799,0.007548059,0.006381403,0.0005272387],"domain_scores_gemma":[0.9748514,0.01630205,0.002385322,0.00404973,0.00223646,0.0001749627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001503826,0.0001860098,0.1372377,0.001243928,0.0009395971,0.0001756791,0.001581389,0.0107846,0.7023256,0.00321907,0.001010411,0.1397921],"study_design_scores_gemma":[0.00003999914,0.001129137,0.1155091,0.0004171072,0.0009364323,0.001210578,0.0003113846,0.0605887,0.8012555,0.005309095,0.01308123,0.0002116318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2721664,0.01006898,0.7091979,0.000521121,0.0004434376,0.0002582174,0.00204196,0.001382682,0.003919327],"genre_scores_gemma":[0.7901382,0.001388441,0.2041444,0.0005296464,0.0001295281,0.0003520027,0.001230475,0.0003031443,0.001784145],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02081157,"threshold_uncertainty_score":0.1100634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02332889641217853,"score_gpt":0.3024085144254725,"score_spread":0.279079618013294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}