{"id":"W2991203221","doi":"10.1182/blood-2019-123678","title":"Genome and Exome-Wide Studies Reveal Potential Predictive Efficacy Markers for Venetoclax and Rituximab (VenR) in Relapsed/Refractory Chronic Lymphocytic Leukemia (R/R CLL): Subgroup Analyses of the Murano Trial","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Venetoclax; Rituximab; Medicine; Chronic lymphocytic leukemia; Oncology; Internal medicine; Refractory (planetary science); Exome; Alemtuzumab; Exome sequencing; Leukemia; Immunology; Lymphoma; Antibody; Biology; Genetics; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001826964,0.0004411651,0.000947156,0.0003902953,0.0002439803,0.0007691918,0.0003406782,0.0004231828,0.001644543],"category_scores_gemma":[0.001979804,0.0001892038,0.002112053,0.0005598294,0.0002105088,0.0003679951,0.0005118204,0.0004932649,0.0001508652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001756568,"about_ca_system_score_gemma":0.0001761905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003958717,"about_ca_topic_score_gemma":0.001390026,"domain_scores_codex":[0.9992312,0.0003125613,0.0000984939,0.0002258266,0.00005833351,0.00007347148],"domain_scores_gemma":[0.9991251,0.0003699256,0.0002231464,0.0001695486,0.00003326646,0.00007909195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1050751,0.0002923856,0.8055289,0.0006613664,0.02703481,0.0006518327,0.000376664,0.00100811,0.01804883,0.0002213507,0.001680057,0.03942068],"study_design_scores_gemma":[0.003143738,0.003022012,0.9703846,0.00008751281,0.01609162,0.0009699477,0.00020767,0.001529789,0.001325878,0.0005189551,0.002686599,0.000031643],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966505,0.002345972,0.0001109228,0.00006998995,0.00001452021,0.00001715083,0.0005269068,0.00000445113,0.0002597282],"genre_scores_gemma":[0.9985661,0.0002485474,0.0001075825,0.0000579283,0.00002644085,0.00002351408,0.000805223,0.000004339033,0.0001603542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001826964,"threshold_uncertainty_score":0.009661973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02810904450633598,"score_gpt":0.318834053566548,"score_spread":0.290725009060212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}