{"id":"W2991203221","doi":"10.1182/blood-2019-123678","title":"Genome and Exome-Wide Studies Reveal Potential Predictive Efficacy Markers for Venetoclax and Rituximab (VenR) in Relapsed/Refractory Chronic Lymphocytic Leukemia (R/R CLL): Subgroup Analyses of the Murano Trial","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Venetoclax; Rituximab; Medicine; Chronic lymphocytic leukemia; Oncology; Internal medicine; Refractory (planetary science); Exome; Alemtuzumab; Exome sequencing; Leukemia; Immunology; Lymphoma; Antibody; Biology; Genetics; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008079727,0.0003223661,0.0009962308,0.0002553963,0.0001074595,0.0000234367,0.0002416916,0.0002337372,0.00001870875],"category_scores_gemma":[0.0008951909,0.0002357651,0.0002319909,0.0003734756,0.0005450915,0.0001027403,0.000296608,0.0003286079,0.000005652401],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.02351652,"about_ca_system_score_gemma":0.01377478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005390359,"about_ca_topic_score_gemma":0.00005208775,"domain_scores_codex":[0.9972376,0.0002195919,0.0007012023,0.0006576839,0.000591181,0.0005927306],"domain_scores_gemma":[0.9976342,0.00113651,0.0002651339,0.0006502477,0.0001569731,0.0001569443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.523201,0.00615016,0.02247603,0.02279459,0.01970039,0.001065158,0.01177881,0.009364235,0.3737007,0.000147464,0.001319682,0.008301808],"study_design_scores_gemma":[0.9018763,0.004998095,0.07336645,0.0009887841,0.001758703,0.0002237274,0.0008311415,0.009906367,0.005312131,0.0001212487,0.0002281544,0.0003888641],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811928,0.01466817,0.000007489498,0.00005051394,0.0002548777,0.00363163,0.00003965913,0.00002976934,0.0001250341],"genre_scores_gemma":[0.9975052,0.001320529,0.0001043603,0.00004203007,0.0003078938,0.0001552364,0.00001862343,0.00005348037,0.0004925738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3786753,"threshold_uncertainty_score":0.9918162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02810904450633598,"score_gpt":0.318834053566548,"score_spread":0.290725009060212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}