{"id":"W2991273563","doi":"10.1002/cncr.32503","title":"Epidermal growth factor receptor mutation analysis in tissue and plasma from the AURA3 trial: Osimertinib versus platinum‐pemetrexed for T790M mutation‐positive advanced non–small cell lung cancer","year":2019,"lang":"en","type":"article","venue":"Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Institutes of Health; AstraZeneca","keywords":"T790M; Osimertinib; Medicine; Pemetrexed; Lung cancer; Internal medicine; Liquid biopsy; Epidermal growth factor receptor; Oncology; Resistance mutation; Digital polymerase chain reaction; Cancer; Chemotherapy; Polymerase chain reaction; Biology; Erlotinib; Gefitinib; Reverse transcriptase; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008657653,0.0002592168,0.0005212074,0.0001679291,0.0001216584,0.00004173519,0.00008725836,0.0001161717,0.0008205069],"category_scores_gemma":[0.0001126776,0.0001947711,0.0001396537,0.0005874328,0.00004354898,0.000193649,0.00002196942,0.0001523714,0.00001377393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000573674,"about_ca_system_score_gemma":0.0003580238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004278985,"about_ca_topic_score_gemma":0.002893549,"domain_scores_codex":[0.9984803,0.00006410739,0.0004132942,0.0005209412,0.0002105965,0.0003107126],"domain_scores_gemma":[0.9981753,0.0009816341,0.0002780463,0.0002247687,0.000223174,0.0001171048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1344579,0.001117485,0.5287664,0.0009154521,0.01767603,0.00007934243,0.05922081,0.02019129,0.033451,0.000163466,0.006726645,0.1972342],"study_design_scores_gemma":[0.3273613,0.002462884,0.502497,0.0007493889,0.01634235,0.000002287264,0.005275792,0.036765,0.1030788,0.00009855517,0.004120419,0.001246122],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894773,0.002183573,0.0006185972,0.001271877,0.0009789065,0.0036408,0.001401815,0.00003410292,0.0003930097],"genre_scores_gemma":[0.9935563,0.0002172033,0.001595949,0.0003121132,0.0002823273,0.001704864,0.0008931034,0.00004508228,0.001393033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1959881,"threshold_uncertainty_score":0.8983975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01788619148795571,"score_gpt":0.3392736489653498,"score_spread":0.3213874574773941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}