{"id":"W2991321573","doi":"10.1016/j.cjca.2019.11.017","title":"HEARTBiT: A Transcriptomic Signature for Excluding Acute Cellular Rejection in Adult Heart Allograft Patients","year":2019,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Transplantation: Methods and Outcomes","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Montreal Heart Institute; University of Alberta; University of Saskatchewan; Mount Sinai Hospital; University of Ottawa; Dalhousie University; Prevention of Organ Failure; University Health Network; University of British Columbia","funders":"Novartis Pharmaceuticals Canada; Genome British Columbia; Astellas Pharma Canada; Genome Canada","keywords":"Medicine; Transcriptome; Signature (topology); Heart transplantation; Cardiology; Internal medicine; Transplantation; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003494273,0.0001078752,0.0005390585,0.000380034,0.00003730755,0.00000822445,0.00005650656,0.0001880104,0.00002103783],"category_scores_gemma":[0.00006232357,0.00009359365,0.0002862767,0.0001199817,0.00003493029,0.00007381779,0.000001159036,0.0003258004,0.000003943901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001368848,"about_ca_system_score_gemma":0.0004251995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003353202,"about_ca_topic_score_gemma":0.001712091,"domain_scores_codex":[0.9990276,0.0001172207,0.0003415026,0.0001361072,0.00008801255,0.0002896146],"domain_scores_gemma":[0.9992431,0.00008734322,0.00007926083,0.00009845603,0.0002267375,0.0002650736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000674004,0.000006278154,0.953624,0.0001325479,0.0003538412,0.0001656948,0.0007725856,0.0005634371,0.0376759,0.0001304042,0.003831715,0.002069584],"study_design_scores_gemma":[0.01174266,0.002164437,0.8864853,0.0003638997,0.0005714337,0.0009593377,0.000389498,0.00006234612,0.004255491,0.0003304437,0.09237744,0.0002976408],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890972,0.0003002148,0.006369027,0.001816564,0.001579076,0.0004093154,0.00004841102,0.000004408573,0.0003758295],"genre_scores_gemma":[0.9955608,0.00004266166,0.003039212,0.0008422484,0.0003246891,0.000004712556,0.00003110799,0.00001720602,0.0001373865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08854572,"threshold_uncertainty_score":0.3816638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01419212933758398,"score_gpt":0.2711882739884796,"score_spread":0.2569961446508956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}