{"id":"W2991321573","doi":"10.1016/j.cjca.2019.11.017","title":"HEARTBiT: A Transcriptomic Signature for Excluding Acute Cellular Rejection in Adult Heart Allograft Patients","year":2019,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Transplantation: Methods and Outcomes","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Montreal Heart Institute; University of Alberta; University of Saskatchewan; Mount Sinai Hospital; University of Ottawa; Dalhousie University; Prevention of Organ Failure; University Health Network; University of British Columbia","funders":"Novartis Pharmaceuticals Canada; Genome British Columbia; Astellas Pharma Canada; Genome Canada","keywords":"Medicine; Transcriptome; Signature (topology); Heart transplantation; Cardiology; Internal medicine; Transplantation; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007387594,0.0003713598,0.0004745253,0.0009323912,0.0003657172,0.001205081,0.000260182,0.0004321075,0.001398586],"category_scores_gemma":[0.001414413,0.0001033754,0.0003807667,0.000901217,0.0002475329,0.0003529906,0.0006118926,0.000539938,0.0003516774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002452151,"about_ca_system_score_gemma":0.0004327381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007632963,"about_ca_topic_score_gemma":0.001763816,"domain_scores_codex":[0.9995277,0.00009596443,0.00005527959,0.0001075459,0.00009960467,0.0001138576],"domain_scores_gemma":[0.9992728,0.0001765468,0.000250394,0.00003217106,0.0001390305,0.0001291204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002057344,0.0001301364,0.94293,0.0001686209,0.0002192436,0.0004028899,0.0001563735,0.0002798817,0.01860033,0.0001974323,0.001946588,0.03291117],"study_design_scores_gemma":[0.00005586955,0.0004517976,0.9882601,0.00009969385,0.0002712778,0.001163679,0.0005669027,0.001529316,0.003868294,0.00047562,0.003230541,0.00002680638],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913605,0.001612148,0.001421548,0.0005135187,0.0001089742,0.00006783869,0.002821175,0.00004795213,0.002046318],"genre_scores_gemma":[0.9924324,0.0005921567,0.002695951,0.0003969244,0.0001657987,0.00007879482,0.002955974,0.00001962852,0.0006625013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001398586,"threshold_uncertainty_score":0.004678786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01419212933758398,"score_gpt":0.2711882739884796,"score_spread":0.2569961446508956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}