{"id":"W2991412921","doi":"10.1212/wnl.0000000000008699","title":"Risks and benefits of unapproved disease-modifying treatments for neurodegenerative disease","year":2019,"lang":"en","type":"letter","venue":"Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Medicine; Placebo; Adverse effect; Internal medicine; Randomized controlled trial; Relative risk; Meta-analysis; Disease; Amyotrophic lateral sclerosis; Clinical trial; Confidence interval; Physical therapy; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04566318,0.002656942,0.01329802,0.00442862,0.0005324962,0.004049741,0.001847006,0.003223361,0.002907076],"category_scores_gemma":[0.1018921,0.001412594,0.03228722,0.002945367,0.002146743,0.002458978,0.001863942,0.00345167,0.0002625102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001909478,"about_ca_system_score_gemma":0.00224724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001423875,"about_ca_topic_score_gemma":0.002213016,"domain_scores_codex":[0.9299061,0.04251409,0.01634841,0.005367641,0.005274469,0.0005892101],"domain_scores_gemma":[0.9233018,0.05864671,0.01329596,0.002218895,0.002018006,0.0005185824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02323926,0.00008412165,0.004959842,0.209448,0.7393252,0.00008236409,0.00009286187,0.0005956503,0.0003971664,0.0004644462,0.0005402635,0.02077079],"study_design_scores_gemma":[0.01799522,0.001945148,0.00873931,0.03240083,0.9335744,0.00019982,0.00008328108,0.0004635123,0.0006204026,0.00154523,0.002385772,0.00004705794],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.01233113,0.9826239,0.00156865,0.0006450426,0.0007215469,0.0007236598,0.000627212,0.00003493776,0.0007239311],"genre_scores_gemma":[0.6689937,0.3155785,0.006491941,0.002497194,0.001633378,0.00315774,0.001038812,0.00005242084,0.0005563657],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.04566318,"threshold_uncertainty_score":0.2414929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1184015270591895,"score_gpt":0.3372287311822071,"score_spread":0.2188272041230176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}