{"id":"W2991415418","doi":"10.22215/etd/2019-13703","title":"Exploration into the MLL4/WRAD Enzyme-Substrate Network: Systematic Identification of CFP1 as a Non-Histone Substrate of the MLL4 Lysine Methyltransferase","year":2019,"lang":"en","type":"dissertation","venue":"","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"Histone methyltransferase; Histone methylation; Histone code; Histone H2A; Histone; EZH2; Cell biology; Biochemistry; Biology; Chemistry; DNA methylation; DNA; Nucleosome; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002363719,0.0003207839,0.0002156669,0.000346796,0.0001497773,0.0004507203,0.0002926931,0.0002141371,0.0009021458],"category_scores_gemma":[0.0001720245,0.0001270415,0.0002370338,0.0003207918,0.0001998429,0.0003877684,0.0003484429,0.00042632,0.0003964597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003558997,"about_ca_system_score_gemma":0.000384125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004447927,"about_ca_topic_score_gemma":0.0006229986,"domain_scores_codex":[0.9999175,0.0000082418,0.000003293177,0.00003055016,0.00002368581,0.00001665798],"domain_scores_gemma":[0.9999467,0.00001024196,0.00001517022,0.000007570444,0.000009267341,0.00001103442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009609537,0.0000279943,0.002637488,0.0001194697,0.0000174883,0.0001628772,0.00004618601,0.0005977288,0.9757591,0.0007186265,0.0001240506,0.0196929],"study_design_scores_gemma":[0.000005891969,0.0001203068,0.009792805,0.00001774461,0.00003394638,0.0002946953,0.00008946683,0.002569999,0.9795716,0.0004773233,0.007018423,0.000007820634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688156,0.007060839,0.01765335,0.0003395254,0.00002223535,0.00005558697,0.000960819,0.00009898021,0.004993038],"genre_scores_gemma":[0.9564456,0.008274705,0.02431392,0.0001343228,0.00001350786,0.00004208298,0.002112592,0.00004994142,0.00861329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009021458,"threshold_uncertainty_score":0.003017962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01150845725808403,"score_gpt":0.2836456918254522,"score_spread":0.2721372345673682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}