{"id":"W2991436030","doi":"10.1182/blood-2019-130362","title":"Enasidenib Plus Azacitidine Significantly Improves Complete Remission and Overall Response Compared with Azacitidine Alone in Patients with Newly Diagnosed Acute Myeloid Leukemia (AML) with Isocitrate Dehydrogenase 2 (IDH2) Mutations: Interim Phase II Results from an Ongoing, Randomized Study","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Azacitidine; IDH2; Isocitrate dehydrogenase; Medicine; Myeloid leukemia; Internal medicine; Interim; Complete remission; Interim analysis; Oncology; Leukemia; IDH1; Gastroenterology; Clinical trial; Biology; Mutation; Chemotherapy; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00157657,0.0008994039,0.002383231,0.0006243594,0.00031575,0.0001796232,0.00039693,0.000210766,0.00005887815],"category_scores_gemma":[0.0005965839,0.0006095537,0.0001170114,0.0007541393,0.0005391261,0.0007026624,0.0002182206,0.000953701,0.00001459701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000726104,"about_ca_system_score_gemma":0.001536282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003139818,"about_ca_topic_score_gemma":0.0009299652,"domain_scores_codex":[0.9933625,0.001321945,0.00135633,0.001672501,0.00133636,0.0009502997],"domain_scores_gemma":[0.9949858,0.00162932,0.0007060905,0.001293138,0.000594787,0.0007908958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8260162,0.005426791,0.01077271,0.00007199512,0.001755586,0.002611814,0.00937061,0.0001871687,0.1434616,0.000002788442,0.00005995495,0.0002626865],"study_design_scores_gemma":[0.8988561,0.03256637,0.03659599,0.001074414,0.001514403,0.0001226334,0.002746264,0.005290519,0.02029843,0.00001760102,0.00003163402,0.0008856165],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892067,0.00009888631,0.0001017267,0.0003202982,0.00003383935,0.009076728,0.0008830244,0.0001962784,0.00008253542],"genre_scores_gemma":[0.9918967,0.00005067014,0.004125103,0.000278994,0.00007906243,0.0004285024,0.002622827,0.0001812316,0.0003369148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1231632,"threshold_uncertainty_score":0.9996356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0157813890202488,"score_gpt":0.2809179710155977,"score_spread":0.2651365819953489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}