{"id":"W2991436030","doi":"10.1182/blood-2019-130362","title":"Enasidenib Plus Azacitidine Significantly Improves Complete Remission and Overall Response Compared with Azacitidine Alone in Patients with Newly Diagnosed Acute Myeloid Leukemia (AML) with Isocitrate Dehydrogenase 2 (IDH2) Mutations: Interim Phase II Results from an Ongoing, Randomized Study","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Azacitidine; IDH2; Isocitrate dehydrogenase; Medicine; Myeloid leukemia; Internal medicine; Interim; Complete remission; Interim analysis; Oncology; Leukemia; IDH1; Gastroenterology; Clinical trial; Biology; Mutation; Chemotherapy; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001566554,0.001114302,0.002443815,0.0003537587,0.0002867882,0.0008632216,0.000653062,0.0009197411,0.004625534],"category_scores_gemma":[0.001054347,0.0003906527,0.001805072,0.0003898249,0.0005737309,0.0008274284,0.000358125,0.002861799,0.0006070834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006301032,"about_ca_system_score_gemma":0.0008179526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005938369,"about_ca_topic_score_gemma":0.002088504,"domain_scores_codex":[0.9995552,0.0002182954,0.0000406106,0.00007084581,0.00004903486,0.00006599564],"domain_scores_gemma":[0.9993029,0.0001771985,0.0001719231,0.00004956332,0.00004057705,0.0002578972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9017194,0.01196411,0.002991298,0.0008927353,0.002672112,0.00005031854,0.00007645904,0.0007124576,0.0079814,0.0000841775,0.002031884,0.06882381],"study_design_scores_gemma":[0.7311495,0.2476069,0.0147405,0.00009684039,0.00228275,0.0001245247,0.00004392319,0.0006389428,0.001392599,0.0001466312,0.001754256,0.00002266724],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847685,0.009003701,0.0003676156,0.0007815112,0.0003612671,0.001229357,0.001191078,0.0001151552,0.002181808],"genre_scores_gemma":[0.9863923,0.005543571,0.001134924,0.001259628,0.0004644088,0.001320831,0.001931608,0.00002401841,0.001928648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004625534,"threshold_uncertainty_score":0.01547396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0157813890202488,"score_gpt":0.2809179710155977,"score_spread":0.2651365819953489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}