{"id":"W2991496398","doi":"10.1007/s13555-019-00340-3","title":"Safety of Ixekizumab Treatment for up to 5 Years in Adult Patients with Moderate-to-Severe Psoriasis: Results from Greater Than 17,000 Patient-Years of Exposure","year":2019,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"Cilag; Sanofi Genzyme; Genentech; Medac; Mitsubishi Tanabe Pharma Corporation; Sanofi; Kyowa Hakko Kirin; LEO Fondet; Astellas Pharma; Regeneron Pharmaceuticals; Mylan; Eli Lilly and Company; Purdue Pharma; Sun Pharma; Dermira; Purdue University; Coherus Biosciences; UCB Pharma; Valeant Pharmaceuticals International; Baxalta; Celgene; Pfizer; Biogen; GlaxoSmithKline; Amgen; Meiji Seika Pharma; Galderma; LEO Pharma; Ortho Dermatologics; Allergan; AstraZeneca; Samsung; Bristol-Myers Squibb","keywords":"Ixekizumab; Psoriasis; Medicine; Dermatology; Psoriatic arthritis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004073018,0.0002225194,0.0005831292,0.0001614439,0.00003958238,0.00000407827,0.0001099874,0.0002663248,0.00006183342],"category_scores_gemma":[0.00001034575,0.0001731886,0.00007544622,0.0001138017,0.00005478901,0.00005553594,0.000022994,0.00005441966,0.00002543269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002376106,"about_ca_system_score_gemma":0.00003198416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002957487,"about_ca_topic_score_gemma":0.0001372422,"domain_scores_codex":[0.9987208,0.0001515629,0.0004168949,0.000391978,0.00004047631,0.0002783108],"domain_scores_gemma":[0.9992316,0.0001708718,0.0001528983,0.0003160797,0.00009376113,0.00003472313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1322955,0.0008464021,0.6563331,0.00002270347,0.001609763,0.0000175727,0.02555343,0.0001171973,0.002397316,0.000134595,0.0003702696,0.1803021],"study_design_scores_gemma":[0.05786419,0.004099513,0.881565,0.0001294234,0.00009953794,0.00001738268,0.0006688056,0.000003521616,0.05181266,0.00009606608,0.003271654,0.0003722669],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963704,0.0004978191,0.000008040979,0.00008134428,0.0003158907,0.001100068,0.001538333,0.00001479938,0.00007328549],"genre_scores_gemma":[0.9986181,0.0002009349,0.000157575,0.0001425035,0.00000658205,0.0001062928,0.000543169,0.00001990718,0.0002049558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2252318,"threshold_uncertainty_score":0.7062427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009983924242019151,"score_gpt":0.2114780800689378,"score_spread":0.2014941558269186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}