{"id":"W2991614103","doi":"10.1073/pnas.1908724116","title":"β2* nAChRs on VTA dopamine and GABA neurons separately mediate nicotine aversion and reward","year":2019,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Ventral tegmental area; Dopamine; Nicotine; Nicotinic agonist; Neuroscience; Dopaminergic; Conditioned place preference; Neurotransmitter; Aversive Stimulus; Pharmacology; Psychology; Medicine; Receptor; Internal medicine; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001436429,0.0003111455,0.0003128239,0.0001817176,0.0002108941,0.0005597685,0.0002710034,0.000426306,0.00188583],"category_scores_gemma":[0.0002258324,0.0001385763,0.0003537251,0.00007888623,0.0003366048,0.0003113197,0.0003138752,0.0008323031,0.0003507926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003316917,"about_ca_system_score_gemma":0.0002130118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002093293,"about_ca_topic_score_gemma":0.002566818,"domain_scores_codex":[0.9998969,0.00001588699,0.000006392382,0.00001744956,0.0000182675,0.00004507592],"domain_scores_gemma":[0.9998975,0.00001433669,0.00001723004,0.000009622417,0.00002465929,0.00003656857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003688931,0.00005711721,0.003226641,0.0000364421,0.00003615954,0.00008871157,0.00004220018,0.0000902238,0.9920059,0.0006101629,0.00009954495,0.003338026],"study_design_scores_gemma":[0.0001597083,0.00119887,0.3315565,0.00009529826,0.0002671918,0.002387335,0.0008466974,0.007464209,0.6493382,0.002845324,0.003802929,0.00003774491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904358,0.001815139,0.003331146,0.0003443036,0.00006748879,0.00001357603,0.00008465055,0.00004279477,0.003865102],"genre_scores_gemma":[0.9959929,0.0006802137,0.0005579577,0.0001139327,0.0000166329,0.00001019164,0.00009447728,0.00001110048,0.002522593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002093293,"threshold_uncertainty_score":0.006308734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01942531610295033,"score_gpt":0.289255748911887,"score_spread":0.2698304328089367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}