{"id":"W2991747883","doi":"10.1063/1.5122967","title":"AAV-mediated gene therapy targeting TRPV4 mechanotransduction for inhibition of pulmonary vascular leakage","year":2019,"lang":"en","type":"article","venue":"APL Bioengineering","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Biomedical Imaging and Bioengineering; National Heart, Lung, and Blood Institute","keywords":"Transient receptor potential channel; Gene delivery; Genetic enhancement; Pulmonary edema; Mechanotransduction; TRPV4; Vascular permeability; Medicine; Transgene; Lung; Cell biology; Pharmacology; Cancer research; Chemistry; Pathology; Gene; Biology; Receptor; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001703617,0.0001364316,0.0001642025,0.0001189742,0.00004472327,0.00001148116,0.00008110631,0.00008886188,0.0000483033],"category_scores_gemma":[0.00004417382,0.0001229384,0.000128563,0.0002420476,0.0000180421,0.000160406,0.00001353619,0.00008574149,0.00001831425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002715023,"about_ca_system_score_gemma":0.00001280551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005702559,"about_ca_topic_score_gemma":6.818332e-8,"domain_scores_codex":[0.9990875,0.0000207112,0.0002178591,0.000271764,0.000168,0.0002341694],"domain_scores_gemma":[0.9996922,0.00006776879,0.00006495375,0.0001008585,0.0000337578,0.00004045859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001895977,0.00002466956,0.000008857874,0.00006738615,0.000006416634,0.000001040302,0.0002361471,0.003810793,0.9946694,0.0001321834,0.000009639015,0.001014503],"study_design_scores_gemma":[0.0003827317,0.0000732945,0.00001672269,0.00002861652,0.000003831991,0.000003330302,0.00004747012,0.04898715,0.9489026,0.00004425363,0.001367604,0.0001423686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752831,0.000211756,0.02265568,0.00007523565,0.001148586,0.0004562887,0.00002092402,0.0001205208,0.00002791771],"genre_scores_gemma":[0.9987668,0.0003550311,0.0005016414,0.00004255792,0.0001745309,0.0000306678,0.00003572708,0.00003616024,0.00005692982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04576678,"threshold_uncertainty_score":0.5013283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01619809483999247,"score_gpt":0.2132898541716227,"score_spread":0.1970917593316302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}