{"id":"W2991747883","doi":"10.1063/1.5122967","title":"AAV-mediated gene therapy targeting TRPV4 mechanotransduction for inhibition of pulmonary vascular leakage","year":2019,"lang":"en","type":"article","venue":"APL Bioengineering","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Biomedical Imaging and Bioengineering; National Heart, Lung, and Blood Institute","keywords":"Transient receptor potential channel; Gene delivery; Genetic enhancement; Pulmonary edema; Mechanotransduction; TRPV4; Vascular permeability; Medicine; Transgene; Lung; Cell biology; Pharmacology; Cancer research; Chemistry; Pathology; Gene; Biology; Receptor; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002382417,0.0002663872,0.0002638818,0.0003087146,0.0002003786,0.0003364772,0.0003213578,0.0004552621,0.001533583],"category_scores_gemma":[0.0001531246,0.0001268727,0.0003116784,0.0001292597,0.0003788699,0.0003169076,0.0002166926,0.0007390727,0.0002578874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003259917,"about_ca_system_score_gemma":0.0004222435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005374643,"about_ca_topic_score_gemma":0.0009002038,"domain_scores_codex":[0.9998454,0.00002265462,0.00001261208,0.00002940787,0.00005064186,0.00003921459],"domain_scores_gemma":[0.9999558,0.00000976115,0.00001316461,0.000004666563,0.000007146247,0.000009558341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004857674,0.00006217992,0.00005581724,0.00006665233,0.000006250283,0.0000412697,0.00001960358,0.0001710611,0.9932364,0.0006530256,0.0001288215,0.005510425],"study_design_scores_gemma":[0.00005773385,0.001007464,0.0008931183,0.00001709735,0.00003860993,0.0004069247,0.000029211,0.002906814,0.9853254,0.0002772964,0.009029505,0.00001082359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8619134,0.008491933,0.1184499,0.0009057708,0.0005596504,0.0004489046,0.00039936,0.0009204395,0.007910609],"genre_scores_gemma":[0.9633521,0.002935755,0.0282675,0.0001315812,0.00003986569,0.0001952654,0.00021043,0.00003933374,0.004828283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001533583,"threshold_uncertainty_score":0.005130291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01619809483999247,"score_gpt":0.2132898541716227,"score_spread":0.1970917593316302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}