{"id":"W2991942259","doi":"10.1101/861641","title":"ADP is the dominant controller of AMP-activated protein kinase activity dynamics in skeletal muscle during exercise","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"AMPK; Protein kinase A; AMP-activated protein kinase; Skeletal muscle; Chemistry; Phosphorylation; Allosteric regulation; Adenine nucleotide; Biochemistry; Cell biology; Kinase; Nucleotide; Biophysics; Enzyme; Biology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002491054,0.0003926074,0.0004583105,0.0001532733,0.000211013,0.000495437,0.0003552228,0.0004628839,0.001176648],"category_scores_gemma":[0.0005628596,0.000232137,0.0005573063,0.0001334165,0.0004209326,0.0004830382,0.0003878499,0.0004836012,0.0001502367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005234149,"about_ca_system_score_gemma":0.0005711254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002517168,"about_ca_topic_score_gemma":0.001373616,"domain_scores_codex":[0.9999251,0.00001660337,0.000004251811,0.00002440177,0.00001617296,0.0000133427],"domain_scores_gemma":[0.999804,0.0001034958,0.00004806837,0.000009238849,0.00002273671,0.00001253212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004739501,0.00003049285,0.001256259,0.00007200975,0.00002587194,0.00009088477,0.00001805842,0.9678788,0.02448829,0.004424667,0.0001426771,0.001524629],"study_design_scores_gemma":[0.00000586078,0.00003153799,0.0004246712,0.000003253763,0.000007370622,0.00001008574,0.00000639345,0.9956247,0.002892411,0.0007907135,0.0001979258,0.000005089264],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7516063,0.0007247528,0.2371269,0.0007155347,0.00004931312,0.00006089374,0.0003673252,0.0001627566,0.009186153],"genre_scores_gemma":[0.9947094,0.0002099239,0.003756844,0.00003742431,0.000004170135,0.00005075523,0.00005560631,0.000009701052,0.001166189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002517168,"threshold_uncertainty_score":0.005005002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007064397914609602,"score_gpt":0.2115117523528355,"score_spread":0.2044473544382259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}