{"id":"W2991974847","doi":"10.14309/01.ajg.0000613172.41188.d4","title":"P051 Phase 1a Safety and Pharmacokinetic Effects of GB004, a Novel Prolyl Hydroxylase Inhibitor and Potential Therapy for Inflammatory Bowel Disease","year":2019,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Erythropoietin; Pharmacokinetics; Tolerability; Placebo; Pharmacology; Inflammatory bowel disease; Vascular endothelial growth factor; Internal medicine; Hypoxia (environmental); Pharmacodynamics; Gastroenterology; Area under the curve; Adverse effect; Pathology; Disease; VEGF receptors","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007188127,0.0005800112,0.0009216,0.000346316,0.0003013173,0.0006255506,0.0006138184,0.0006755714,0.00336308],"category_scores_gemma":[0.0005761305,0.0002790978,0.0005501529,0.0003225613,0.000665794,0.0003396606,0.0001683403,0.001609835,0.0005802098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001142145,"about_ca_system_score_gemma":0.002245348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003067689,"about_ca_topic_score_gemma":0.005765965,"domain_scores_codex":[0.9997413,0.0000951422,0.00001155437,0.00004098947,0.00006099254,0.00005008375],"domain_scores_gemma":[0.9996811,0.00004603541,0.00008059242,0.00003025128,0.00005368438,0.0001084588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4996862,0.04562029,0.006536335,0.00110724,0.0006616202,0.0002617023,0.0002834463,0.002388906,0.2777135,0.0004583727,0.005808028,0.1594743],"study_design_scores_gemma":[0.1715231,0.7243202,0.03433362,0.00005985442,0.000688191,0.0004813308,0.0001022564,0.001986585,0.05202396,0.0002707989,0.01417258,0.00003757171],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913192,0.001944268,0.001226629,0.000282866,0.00005531409,0.001672837,0.001442716,0.000123911,0.00193222],"genre_scores_gemma":[0.9879709,0.001350524,0.002437354,0.0004749114,0.00007689041,0.001308398,0.002190103,0.00003457552,0.004156308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00336308,"threshold_uncertainty_score":0.01125062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002870296975822434,"score_gpt":0.2344027746413684,"score_spread":0.231532477665546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}