{"id":"W2992010002","doi":"10.1158/1535-7163.targ-19-b057","title":"Abstract B057: BMS-986148, an anti-mesothelin antibody-drug conjugate (ADC), alone or in combination with nivolumab demonstrates clinical activity in patients with select advanced solid tumors","year":2019,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Mesothelin; Nivolumab; Medicine; Mesothelioma; Pharmacology; Pharmacokinetics; Antibody-drug conjugate; Ovarian cancer; Cancer; Internal medicine; Monoclonal antibody; Oncology; Antibody; Immunology; Immunotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002633708,0.0003442911,0.0004706426,0.000113231,0.00005399242,0.00005562348,0.0002475869,0.0001563459,0.00002828387],"category_scores_gemma":[0.00001064886,0.0002674113,0.00006974092,0.0003203033,0.0001490347,0.00004209093,0.00004912428,0.0003379279,0.000006844271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001276757,"about_ca_system_score_gemma":0.00058753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007130422,"about_ca_topic_score_gemma":0.004960143,"domain_scores_codex":[0.9977351,0.0002057359,0.0003860794,0.0007193348,0.0003871807,0.0005665831],"domain_scores_gemma":[0.9989433,0.00002633563,0.0002180258,0.0004960108,0.0001801278,0.0001361713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006555581,0.001554142,0.7443492,0.00004674491,0.0002722439,0.0000656288,0.00005117592,0.001289299,0.2311001,0.000003387906,0.000003401861,0.01470913],"study_design_scores_gemma":[0.01525489,0.003353866,0.7539398,0.0001690479,0.00003829017,0.00000310753,0.0000406073,0.0004236788,0.2261247,0.00001503592,0.0001816701,0.0004552823],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980525,0.0004552628,0.0001112833,0.0001069742,0.00005779378,0.001072064,0.00006272519,0.00001819458,0.00006324373],"genre_scores_gemma":[0.9984491,0.0005004926,0.0002533769,0.0003008036,0.00002368806,0.00007696604,0.0002644825,0.00007432918,0.00005678071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01425384,"threshold_uncertainty_score":0.9999778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01372410448235262,"score_gpt":0.3358645187573308,"score_spread":0.3221404142749781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}