{"id":"W2992010002","doi":"10.1158/1535-7163.targ-19-b057","title":"Abstract B057: BMS-986148, an anti-mesothelin antibody-drug conjugate (ADC), alone or in combination with nivolumab demonstrates clinical activity in patients with select advanced solid tumors","year":2019,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Mesothelin; Nivolumab; Medicine; Mesothelioma; Pharmacology; Pharmacokinetics; Antibody-drug conjugate; Ovarian cancer; Cancer; Internal medicine; Monoclonal antibody; Oncology; Antibody; Immunology; Immunotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002369202,0.0003584396,0.0007039922,0.0001850877,0.0001549833,0.0003459771,0.0001962742,0.0002862992,0.002975192],"category_scores_gemma":[0.0001854999,0.0001244919,0.0002852309,0.0001826372,0.0001870725,0.0002517363,0.0001520394,0.0009244595,0.0006620071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002945289,"about_ca_system_score_gemma":0.0004291737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004402473,"about_ca_topic_score_gemma":0.0007901321,"domain_scores_codex":[0.999908,0.00002665021,0.000007168171,0.00001682084,0.00001712771,0.00002422365],"domain_scores_gemma":[0.9998937,0.0000161193,0.00001465382,0.000007413982,0.000008344194,0.00005976305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1665135,0.02406358,0.01579062,0.0006579202,0.0005212811,0.0004967772,0.0001890235,0.001891715,0.5332355,0.0002733566,0.007882682,0.248484],"study_design_scores_gemma":[0.1020244,0.5324396,0.1220237,0.00008586941,0.000869585,0.002262532,0.0001496514,0.005652122,0.2134844,0.000239383,0.02073001,0.00003877901],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971413,0.0009718892,0.0001815985,0.0001046613,0.00002922024,0.0001310745,0.0002668539,0.00005659259,0.00111679],"genre_scores_gemma":[0.9974092,0.0004228262,0.0002988695,0.00008839925,0.00003421793,0.00009473044,0.000715595,0.000007981985,0.0009283049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002975192,"threshold_uncertainty_score":0.009953022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01372410448235262,"score_gpt":0.3358645187573308,"score_spread":0.3221404142749781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}