{"id":"W2992092023","doi":"10.3390/cancers11121930","title":"Direct Targeting Options for STAT3 and STAT5 in Cancer","year":2019,"lang":"en","type":"review","venue":"Cancers","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Research, Development and Innovation Office; Natural Sciences and Engineering Research Council of Canada; Hungarian Scientific Research Fund; Canadian Institutes of Health Research; Austrian Science Fund; Canadian Cancer Society; Ontario Research Foundation","keywords":"STAT3; Cancer research; STAT5; STAT protein; Leukemia; Biology; Myeloid leukemia; STAT1; Cancer; Transcription factor; Cell biology; Signal transduction; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000258954,0.0005729858,0.0006453549,0.001245092,0.0001703389,0.000465974,0.0004882712,0.0006417255,0.004084261],"category_scores_gemma":[0.0002175289,0.0001895212,0.0004128365,0.0007600131,0.0002202495,0.0006790193,0.0004833947,0.001418567,0.0019486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003105442,"about_ca_system_score_gemma":0.0003732067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004570926,"about_ca_topic_score_gemma":0.001242101,"domain_scores_codex":[0.9999162,0.00001387525,0.00001065577,0.00001601103,0.00003122086,0.00001202376],"domain_scores_gemma":[0.9999403,0.00002682349,0.000009788397,0.000002306989,0.00001324391,0.000007529872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001235687,0.0001038437,0.0001293376,0.01347338,0.00008394228,0.0002515612,0.00004775958,0.0004291807,0.008398339,0.004947515,0.02682679,0.9451847],"study_design_scores_gemma":[0.0000297814,0.0001572767,0.0004986095,0.001374888,0.00008155253,0.001290933,0.00002311027,0.0001097457,0.001478754,0.001531671,0.9934096,0.0000141775],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002680146,0.9976283,0.000189553,0.0001756017,0.0001690939,0.000006454548,0.00002666782,0.00001091546,0.001525538],"genre_scores_gemma":[0.00195109,0.995952,0.0002640466,0.0002941829,0.0001297783,0.00001030561,0.00008081062,0.000002450676,0.001315376],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004084261,"threshold_uncertainty_score":0.01366323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1216853278648594,"score_gpt":0.425011177798573,"score_spread":0.3033258499337136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}