{"id":"W2992109752","doi":"10.3389/fncel.2019.00556","title":"Functional Genomics of Epilepsy and Associated Neurodevelopmental Disorders Using Simple Animal Models: From Genes, Molecules to Brain Networks","year":2019,"lang":"en","type":"review","venue":"Frontiers in Cellular Neuroscience","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Simon Fraser University","funders":"Medical Research Council; Rare Disease Foundation; Wellcome Trust","keywords":"Epilepsy; Neuroscience; Genomics; Functional genomics; Animal model; Gene; Biology; Computational biology; Medicine; Genetics; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004930781,0.0005773055,0.0007888437,0.0006533813,0.0001493763,0.0007477169,0.0003900868,0.0006351168,0.0008954586],"category_scores_gemma":[0.0002524947,0.0002155984,0.0004898765,0.0003868231,0.0005631829,0.0007315333,0.000380346,0.001017999,0.0005227423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000515443,"about_ca_system_score_gemma":0.0003705067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004830723,"about_ca_topic_score_gemma":0.0007114398,"domain_scores_codex":[0.9998649,0.00003159564,0.0000141834,0.00002744684,0.00004540925,0.00001638645],"domain_scores_gemma":[0.9998865,0.00004884232,0.00002379788,0.00001128412,0.00001742133,0.00001210801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000189072,0.00006902783,0.0009196094,0.005901739,0.0001441395,0.0008203232,0.0001983877,0.002118466,0.7970571,0.04611658,0.007840743,0.1386249],"study_design_scores_gemma":[0.0000469694,0.0007460109,0.008363851,0.0009787158,0.0004048418,0.00426771,0.0001970693,0.003174728,0.241227,0.02798339,0.7124899,0.000119776],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07947708,0.7524194,0.1339778,0.005243324,0.001294679,0.000203062,0.002891381,0.001227895,0.02326538],"genre_scores_gemma":[0.1558514,0.7756811,0.05705941,0.001326034,0.000389546,0.0002312428,0.002429571,0.0001600262,0.00687173],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0008954586,"threshold_uncertainty_score":0.003739834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0342259988690869,"score_gpt":0.250915952429807,"score_spread":0.2166899535607201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}