{"id":"W2992176081","doi":"10.1038/s41416-019-0640-1","title":"Serotonin activates glycolysis and mitochondria biogenesis in human breast cancer cells through activation of the Jak1/STAT3/ERK1/2 and adenylate cyclase/PKA, respectively","year":2019,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universidade Federal do Rio de Janeiro; Institut National Du Cancer; Ministério da Ciência, Tecnologia e Inovação; Johns Hopkins University; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Université Laval; American University of Beirut","keywords":"PKM2; Adenylyl cyclase; Biology; Glycolysis; Anaerobic glycolysis; Downregulation and upregulation; Pyruvate kinase; Cancer cell; Cell biology; Signal transduction; Endocrinology; Chemistry; Internal medicine; Biochemistry; Metabolism; Cancer; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001365239,0.000147209,0.0003218961,0.00006125334,0.00007585627,0.00004725785,0.0001561981,0.0001323546,0.0000717263],"category_scores_gemma":[0.00001844896,0.0001349724,0.0001095723,0.0001807491,0.0001187718,0.00004085594,0.00007650378,0.0001757225,1.625761e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005633116,"about_ca_system_score_gemma":0.0001891957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003826693,"about_ca_topic_score_gemma":0.002962611,"domain_scores_codex":[0.998902,0.00008797489,0.0003519995,0.0002553297,0.0002069427,0.0001957342],"domain_scores_gemma":[0.9991443,0.00001716146,0.000423188,0.0001444367,0.0002110111,0.00005989231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003138285,0.00004085062,0.01738707,0.0000453436,0.0001392937,0.000001877288,0.0001568905,0.0001438083,0.9678264,0.000005943675,0.0007054375,0.01323321],"study_design_scores_gemma":[0.001550879,0.00006328308,0.2900143,0.0003653788,0.00006694368,0.0001193064,0.0001468392,0.000004517464,0.6976515,0.00006417221,0.00980373,0.0001491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810504,0.0176878,0.00001432506,0.0002444489,0.0004795362,0.0002710861,0.0001857373,0.000001831245,0.00006488634],"genre_scores_gemma":[0.9761567,0.02268159,0.00009593683,0.000134856,0.0005555413,0.00002292162,0.000002755558,0.0000241841,0.0003255731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2726273,"threshold_uncertainty_score":0.5784841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005777100606841385,"score_gpt":0.2506204117598505,"score_spread":0.2448433111530091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}