{"id":"W2992232652","doi":"10.1096/fj.201901467r","title":"Identification of novel dynamin‐related protein 1 (Drp1) GTPase inhibitors: <i>Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia‐reperfusion injury</i>","year":2019,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; U.S. Department of Health and Human Services; Government of Canada; National Institutes of Health; Canada Research Chairs","keywords":"Dynamin; GTPase; Medicine; Cancer; Ischemia; Reperfusion injury; Identification (biology); Cardiology; Internal medicine; Biology; Cell biology; Receptor; Endocytosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001377531,0.0004764843,0.0005063076,0.0004930604,0.0001627131,0.0003030104,0.0003003267,0.0003235373,0.001510874],"category_scores_gemma":[0.00008908781,0.0001430179,0.0004540836,0.0003075114,0.000131442,0.0002763048,0.0002269306,0.0005510623,0.0004239039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002653676,"about_ca_system_score_gemma":0.00029879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004259437,"about_ca_topic_score_gemma":0.001257145,"domain_scores_codex":[0.9999437,0.000007218906,0.00000419503,0.00001413808,0.00001328166,0.00001747749],"domain_scores_gemma":[0.9999593,0.000004260761,0.00001311296,0.00000284792,0.000007687127,0.0000128234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000913982,0.0006454239,0.0009225123,0.0008936471,0.0001071471,0.0004779181,0.00006388584,0.002984411,0.9323143,0.001058378,0.001693328,0.057925],"study_design_scores_gemma":[0.0009665491,0.0089939,0.008605131,0.0001365723,0.0005467224,0.002476098,0.00008072204,0.008057284,0.9191903,0.0004786321,0.05037135,0.00009677762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9453046,0.03249981,0.008562052,0.0009129327,0.00009877093,0.0004969187,0.002238434,0.0003662784,0.009520174],"genre_scores_gemma":[0.9646956,0.01772845,0.0088964,0.0006007106,0.00004120892,0.0002120848,0.002854401,0.0000288587,0.004942416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001510874,"threshold_uncertainty_score":0.005054414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004288976763301026,"score_gpt":0.2165339756172759,"score_spread":0.2122449988539749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}