{"id":"W2992232652","doi":"10.1096/fj.201901467r","title":"Identification of novel dynamin‐related protein 1 (Drp1) GTPase inhibitors: <i>Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia‐reperfusion injury</i>","year":2019,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; U.S. Department of Health and Human Services; Government of Canada; National Institutes of Health; Canada Research Chairs","keywords":"Dynamin; GTPase; Medicine; Cancer; Ischemia; Reperfusion injury; Identification (biology); Cardiology; Internal medicine; Biology; Cell biology; Receptor; Endocytosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004126124,0.0001026457,0.0001559096,0.00005132469,0.00004430908,0.00001483903,0.00008281123,0.0001285802,0.00001140933],"category_scores_gemma":[0.000007330095,0.00007972344,0.00006914856,0.00007704255,0.00009531474,0.0000111588,0.00003104957,0.0001578059,3.505494e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001234251,"about_ca_system_score_gemma":0.00005174391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000726139,"about_ca_topic_score_gemma":0.000008383563,"domain_scores_codex":[0.9991652,0.0000461867,0.0003649761,0.0001557028,0.0001542761,0.0001137092],"domain_scores_gemma":[0.9994831,0.000004816354,0.000239828,0.0001502594,0.00007965988,0.00004230261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001923196,0.00005489797,0.01720355,0.00004149034,0.00003731796,6.305905e-7,0.0001332742,0.00005139121,0.9811134,0.00002104819,0.000003575816,0.001147119],"study_design_scores_gemma":[0.0007627807,0.0001498664,0.004280564,0.00007945661,0.00004353216,0.0000101414,0.0001518857,0.0004986323,0.9938008,0.00003342883,0.0000952341,0.00009365055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964626,0.002467657,0.0004350517,0.00007822185,0.0002493217,0.0002638522,0.00002905189,0.000001882416,0.00001237778],"genre_scores_gemma":[0.9988757,0.0007403356,0.00001869014,0.000008132863,0.0001143543,0.000005794562,0.00006989274,0.00001198168,0.000155112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01292299,"threshold_uncertainty_score":0.3251027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004288976763301026,"score_gpt":0.2165339756172759,"score_spread":0.2122449988539749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}