{"id":"W2992277868","doi":"10.1182/blood.v106.11.2982.2982","title":"The Induction of Apoptosis by Histone Deacetylase Inhibition in Chronic Lymphocytic Leukemia (CLL) Cells Is Mediated through the TNF-Related Apoptosis-Inducing Ligand (TRAIL) Pathway.","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba","funders":"","keywords":"Apoptosis; Histone deacetylase; Viability assay; Acridine orange; MTT assay; Molecular biology; Trichostatin A; Histone deacetylase inhibitor; Cell cycle; Jurkat cells; Cancer research; Chemistry; Biology; Immunology; Histone; Biochemistry; T cell; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001763231,0.0002875139,0.0002456977,0.0002438756,0.0001655441,0.0002545005,0.0001237456,0.0001591151,0.001401371],"category_scores_gemma":[0.0001065364,0.00008748615,0.0002374989,0.0002491413,0.0001489299,0.0001280608,0.0001346821,0.0003552697,0.0003736998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004291135,"about_ca_system_score_gemma":0.000260742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007042604,"about_ca_topic_score_gemma":0.001630837,"domain_scores_codex":[0.9998603,0.00002297414,0.00002025211,0.00001769864,0.00004251253,0.00003622997],"domain_scores_gemma":[0.9999046,0.00002196408,0.00002899547,0.00001012286,0.00001787591,0.00001637844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002588957,0.00006711522,0.001054291,0.0001045683,0.00001114104,0.00006444319,0.00001761164,0.00003673474,0.9936048,0.00002963815,0.0001171843,0.004633508],"study_design_scores_gemma":[0.00007426969,0.001709901,0.0136215,0.00001616053,0.00003053451,0.0005396443,0.00004423306,0.0002819133,0.9794425,0.00002386534,0.004211593,0.000003876907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881544,0.007597225,0.001641546,0.0001248258,0.00004824723,0.00005484847,0.0006993284,0.00008814351,0.001591275],"genre_scores_gemma":[0.9926146,0.003753317,0.001296379,0.00005143019,0.00002007423,0.00004466957,0.0009809247,0.000006119821,0.001232448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001401371,"threshold_uncertainty_score":0.004688025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01372189774317181,"score_gpt":0.2652038972538385,"score_spread":0.2514819995106667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}