{"id":"W2992307477","doi":"10.1182/blood.2019003863","title":"Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":226,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; European Hematology Association","keywords":"Complement system; Antiphospholipid syndrome; Lupus anticoagulant; Antibody; Immunology; Atypical hemolytic uremic syndrome; Alternative complement pathway; Biology; Complement membrane attack complex; Eculizumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003940256,0.0001246368,0.0003626646,0.0001193097,0.00005851197,0.00002001913,0.0000467577,0.0000483874,0.00007696924],"category_scores_gemma":[0.00004224242,0.0001011617,0.00001880665,0.0001627578,0.00007200735,0.00004891691,0.0001010058,0.0001312766,0.000007170831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001217871,"about_ca_system_score_gemma":0.00008187543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002338305,"about_ca_topic_score_gemma":0.001022269,"domain_scores_codex":[0.9987486,0.00009640268,0.0001885772,0.0002801912,0.0004227473,0.0002634792],"domain_scores_gemma":[0.9993228,0.0001300393,0.0001002866,0.0002489303,0.00008407054,0.0001139112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002879265,0.0004503705,0.9796451,0.000247341,0.0002184179,0.00001900436,0.000912766,0.000001382723,0.01824725,0.00005026537,0.00009703281,0.00008224642],"study_design_scores_gemma":[0.008898249,0.0002785084,0.9831275,0.0006056193,0.0001068241,0.0002916556,0.001628982,0.0001478411,0.004728238,0.00002999923,0.00003829125,0.0001183332],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976658,0.0002134296,0.000006948901,0.0003543267,0.00001753283,0.00108747,0.00004710994,0.00002751816,0.0005798901],"genre_scores_gemma":[0.9994542,0.00002613798,0.0002183163,0.00004295973,0.00001670691,0.00005353453,0.00004097323,0.00001968815,0.0001274768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01351902,"threshold_uncertainty_score":0.4125254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03752766617050179,"score_gpt":0.3010767877215434,"score_spread":0.2635491215510417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}