{"id":"W2992307477","doi":"10.1182/blood.2019003863","title":"Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":226,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; European Hematology Association","keywords":"Complement system; Antiphospholipid syndrome; Lupus anticoagulant; Antibody; Immunology; Atypical hemolytic uremic syndrome; Alternative complement pathway; Biology; Complement membrane attack complex; Eculizumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005666793,0.0005487452,0.000428245,0.002365418,0.0003397891,0.0004621029,0.0003210791,0.0008810209,0.002279375],"category_scores_gemma":[0.002822832,0.0002542783,0.0004561332,0.001419004,0.0005033502,0.0002977196,0.0004296115,0.0004920383,0.0003202616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001343015,"about_ca_system_score_gemma":0.0002115587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000576787,"about_ca_topic_score_gemma":0.0002996415,"domain_scores_codex":[0.9991168,0.0001893803,0.0001423137,0.0001970281,0.0002232178,0.0001312085],"domain_scores_gemma":[0.9979764,0.0005843114,0.0008545665,0.0001186524,0.0001663071,0.0002998693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006893284,0.00008307381,0.9781808,0.00004619325,0.0001120963,0.006737832,0.0001487617,0.0001147479,0.008465893,0.0001760002,0.0001342331,0.005111006],"study_design_scores_gemma":[0.0000294571,0.0003070241,0.9590818,0.00001986167,0.0001262513,0.03795706,0.0001394143,0.0004433535,0.001208631,0.0001766791,0.0004974803,0.00001305173],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981923,0.0006542739,0.0002222162,0.0000387629,0.000008001914,0.000009599312,0.00007864859,0.00001287066,0.000783426],"genre_scores_gemma":[0.9994445,0.0001595396,0.000138303,0.00002105256,0.00002279409,0.000004430009,0.0001083241,0.000003047582,0.00009797041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002365418,"threshold_uncertainty_score":0.007625282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03752766617050179,"score_gpt":0.3010767877215434,"score_spread":0.2635491215510417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}