{"id":"W2992355457","doi":"10.1016/j.cell.2019.11.016","title":"Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS","year":2019,"lang":"en","type":"article","venue":"Cell","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":205,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; Université de Montréal","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; Dana-Farber Cancer Institute; Deutsche Forschungsgemeinschaft; National Cancer Institute; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; European Molecular Biology Organization; National Multiple Sclerosis Society","keywords":"Biology; Astrocyte; Inflammation; Multiple sclerosis; Experimental autoimmune encephalomyelitis; Sphingolipid; Immune system; Cell biology; Lipid signaling; Immunology; Central nervous system; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002160011,0.0003368714,0.0002254617,0.0002642524,0.0002988096,0.001057167,0.0002797158,0.0004085682,0.00124872],"category_scores_gemma":[0.0002029204,0.0001325061,0.0003278158,0.0002034687,0.0003464362,0.0006611632,0.0004861421,0.0005918866,0.0003529071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005458923,"about_ca_system_score_gemma":0.000274707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004723485,"about_ca_topic_score_gemma":0.0006513117,"domain_scores_codex":[0.9997951,0.00004092395,0.00001985952,0.00003984236,0.00004186456,0.00006237331],"domain_scores_gemma":[0.9998802,0.000008527957,0.00004393189,0.0000155071,0.00002844607,0.00002325372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004638942,0.00002114956,0.0005862947,0.00007515924,0.00001773497,0.0002011953,0.00003992903,0.000144208,0.9935566,0.002401237,0.0001603289,0.002332265],"study_design_scores_gemma":[0.00005118467,0.0003175482,0.01374991,0.00002710109,0.00003263427,0.001049437,0.0003130356,0.002454369,0.9691106,0.002939553,0.009935034,0.00001969478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9681544,0.009861231,0.01360059,0.00147546,0.0001726764,0.00004072614,0.0008245226,0.0001923309,0.005678122],"genre_scores_gemma":[0.9947114,0.001534715,0.001502742,0.0000678448,0.00002191073,0.00002666583,0.000245206,0.00001796323,0.001871515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00124872,"threshold_uncertainty_score":0.004177392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00261397698882532,"score_gpt":0.1873946659391411,"score_spread":0.1847806889503158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}