{"id":"W2992355457","doi":"10.1016/j.cell.2019.11.016","title":"Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS","year":2019,"lang":"en","type":"article","venue":"Cell","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":205,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; Université de Montréal","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; Dana-Farber Cancer Institute; Deutsche Forschungsgemeinschaft; National Cancer Institute; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; European Molecular Biology Organization; National Multiple Sclerosis Society","keywords":"Biology; Astrocyte; Inflammation; Multiple sclerosis; Experimental autoimmune encephalomyelitis; Sphingolipid; Immune system; Cell biology; Lipid signaling; Immunology; Central nervous system; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008762252,0.0001078155,0.0001700554,0.00002330058,0.00001973003,0.000004732462,0.0001349612,0.00009790935,0.00009342273],"category_scores_gemma":[0.000007970365,0.0001025278,0.0001402047,0.00004209768,0.00003042717,0.000003311504,0.00004319429,0.00006241542,0.0001112044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002650558,"about_ca_system_score_gemma":0.00003907359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009286792,"about_ca_topic_score_gemma":0.000002926025,"domain_scores_codex":[0.999398,0.00004051817,0.0001210685,0.0001853039,0.00007063514,0.0001844659],"domain_scores_gemma":[0.9994991,0.000005872064,0.00008675708,0.0003330722,0.00004562209,0.00002962325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000129575,0.00005216505,0.00200513,0.0000175955,0.00003925109,3.851816e-7,0.00001700257,0.00003953595,0.9952136,0.000007865032,0.00007683437,0.00240109],"study_design_scores_gemma":[0.001271022,0.0001735584,0.006467241,0.00000217016,0.000025863,0.000001403772,0.0000222881,0.00007066772,0.9606273,0.000008439502,0.03121613,0.0001139298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911729,0.001990295,0.001783345,0.00001382979,0.0001443196,0.0001655705,0.00001477155,0.000005051952,0.004709963],"genre_scores_gemma":[0.9982056,0.0001309696,0.00005709718,0.00008274932,0.00004499357,0.000007188083,0.00003239117,0.00001461745,0.001424406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03458628,"threshold_uncertainty_score":0.4180964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00261397698882532,"score_gpt":0.1873946659391411,"score_spread":0.1847806889503158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}