{"id":"W2992427983","doi":"10.1158/1940-6207.capr-18-0262","title":"A Phase IIa Trial of Metformin for Colorectal Cancer Risk Reduction among Individuals with History of Colorectal Adenomas and Elevated Body Mass Index","year":2019,"lang":"en","type":"article","venue":"Cancer Prevention Research","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Center for Research Resources; National Cancer Institute; National Institutes of Health","keywords":"Colorectal cancer; Metformin; Medicine; Body mass index; Internal medicine; Oncology; Cancer; Gastroenterology; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002464498,0.001359557,0.001556611,0.0004361304,0.0006262739,0.000855114,0.0006294705,0.001627181,0.00356255],"category_scores_gemma":[0.001166581,0.0006641792,0.001182721,0.0003243153,0.0006582029,0.0005918829,0.0003809913,0.002268087,0.0005622079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005347887,"about_ca_system_score_gemma":0.001267245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007629963,"about_ca_topic_score_gemma":0.002476354,"domain_scores_codex":[0.9993709,0.0003774781,0.00003256354,0.00008434442,0.00004270342,0.00009212237],"domain_scores_gemma":[0.999307,0.0001279035,0.0001465032,0.00006797312,0.00005997828,0.0002905987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.955838,0.0158634,0.003739041,0.0002814818,0.0007967606,0.0000544648,0.00004942042,0.0002694529,0.009358559,0.00009926267,0.001017825,0.01263233],"study_design_scores_gemma":[0.7355816,0.2477616,0.01285082,0.00003521159,0.0006004171,0.00007115276,0.00003680485,0.0005771666,0.001204918,0.0001384624,0.001122501,0.00001932012],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899098,0.002079666,0.0004070349,0.0007206534,0.0002649307,0.003754159,0.0009437999,0.00007487737,0.001845181],"genre_scores_gemma":[0.9885101,0.001126092,0.001520908,0.001295726,0.000362776,0.003433891,0.001286983,0.00001438402,0.002449226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00356255,"threshold_uncertainty_score":0.01303369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02662001491729057,"score_gpt":0.3543165128378128,"score_spread":0.3276964979205222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}