{"id":"W2992443555","doi":"10.1038/s41591-019-0672-3","title":"Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis","year":2019,"lang":"en","type":"article","venue":"Nature Medicine","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"NHLBI Division of Intramural Research; National Institute of Biomedical Imaging and Bioengineering; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute; National Center for Advancing Translational Sciences; Agence Nationale de la Recherche; Georgia Clinical and Translational Science Alliance; Novo Nordisk Fonden; Lundbeckfonden; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Institut National de la Santé et de la Recherche Médicale; Northwestern University; National Institute of Allergy and Infectious Diseases; Université Paris Descartes; Feinberg School of Medicine; New York Stem Cell Foundation; H. Lundbeck A/S; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Encephalitis; Neuroscience; Immunity; Herpes simplex virus; Virology; HSL and HSV; Biology; Immunology; Medicine; Immune system; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001404567,0.0001302164,0.0001555725,0.00004459184,0.0001046397,0.00001407338,0.0001155259,0.0001974746,0.0003030083],"category_scores_gemma":[0.0002579423,0.0001068538,0.00003596972,0.0001251312,0.00008856663,0.000004476147,0.00008149013,0.0001902608,0.00001728517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001261853,"about_ca_system_score_gemma":0.00004688757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000456823,"about_ca_topic_score_gemma":0.00003903068,"domain_scores_codex":[0.9991322,0.00008041944,0.0001722023,0.0002694228,0.0001691201,0.0001766903],"domain_scores_gemma":[0.9992607,0.00002972771,0.00004316947,0.0003403038,0.00009357273,0.0002325868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000334026,0.0003469558,0.0453149,0.0001263475,0.0001559363,0.0000286327,0.0004966875,0.00005769408,0.8619739,0.02408617,0.03609174,0.03098703],"study_design_scores_gemma":[0.001850294,0.000652372,0.8733028,0.0000289039,0.00004865816,0.00001843288,0.00016322,0.00007780086,0.002274733,0.0005459257,0.1208187,0.0002182206],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933041,0.0007136338,0.0002769549,0.003346538,0.0002134981,0.0002509423,0.00001554666,0.0000220404,0.001856743],"genre_scores_gemma":[0.994047,0.00002520591,0.0001007431,0.004036841,0.0003148668,0.000006879387,0.0001863487,0.00001369942,0.001268354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8596991,"threshold_uncertainty_score":0.4357373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007803316942276166,"score_gpt":0.2899540648739759,"score_spread":0.2821507479316998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}