{"id":"W2992443555","doi":"10.1038/s41591-019-0672-3","title":"Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis","year":2019,"lang":"en","type":"article","venue":"Nature Medicine","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"NHLBI Division of Intramural Research; National Institute of Biomedical Imaging and Bioengineering; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute; National Center for Advancing Translational Sciences; Agence Nationale de la Recherche; Georgia Clinical and Translational Science Alliance; Novo Nordisk Fonden; Lundbeckfonden; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Institut National de la Santé et de la Recherche Médicale; Northwestern University; National Institute of Allergy and Infectious Diseases; Université Paris Descartes; Feinberg School of Medicine; New York Stem Cell Foundation; H. Lundbeck A/S; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Encephalitis; Neuroscience; Immunity; Herpes simplex virus; Virology; HSL and HSV; Biology; Immunology; Medicine; Immune system; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007906955,0.0004084196,0.0001761706,0.0002515369,0.0001515785,0.0001457475,0.0001394882,0.0002385572,0.001779186],"category_scores_gemma":[0.0001206842,0.0000988527,0.0001436241,0.000137077,0.0003044884,0.00008674638,0.000203273,0.000232349,0.0002567706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001846572,"about_ca_system_score_gemma":0.0001349785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005002104,"about_ca_topic_score_gemma":0.001092163,"domain_scores_codex":[0.9999185,0.00001181294,0.00001117007,0.00002588911,0.00001598901,0.00001664166],"domain_scores_gemma":[0.9999264,0.00001552162,0.00002592507,0.000008644613,0.000005220147,0.00001825696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002440913,0.00003162989,0.002685745,0.00003185049,0.00002773874,0.001083265,0.00003741566,0.0001654813,0.9922097,0.000202482,0.00007442816,0.003206065],"study_design_scores_gemma":[0.00004507072,0.0007393691,0.06674033,0.00001645652,0.00009684319,0.01730107,0.0001392026,0.001791727,0.9089026,0.0004895771,0.003716254,0.00002147156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979362,0.0002343523,0.0008338143,0.00002126768,0.000006909308,0.00001528098,0.0002398899,0.00004510826,0.000667145],"genre_scores_gemma":[0.9990947,0.0001047491,0.0003047556,0.00001163297,0.000001520617,0.000006600485,0.0001120945,0.000008151366,0.0003557528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001779186,"threshold_uncertainty_score":0.005952001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007803316942276166,"score_gpt":0.2899540648739759,"score_spread":0.2821507479316998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}