{"id":"W2992595646","doi":"10.3390/molecules24244492","title":"Methyltransferase Inhibitors: Competing with, or Exploiting the Bound Cofactor","year":2019,"lang":"en","type":"review","venue":"Molecules","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Structural Genomics Consortium; Princess Margaret Cancer Centre; University of Toronto","funders":"Novartis Pharma; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Genome Canada; Ontario Genomics; Natural Sciences and Engineering Research Council of Canada; Pfizer","keywords":"Druggability; Cofactor; Methyltransferase; Binding site; Chemical biology; Enzyme; Chemistry; Transferase; Biochemistry; Active site; Drug discovery; Plasma protein binding; Stereochemistry; Biology; DNA; Methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002329948,0.0004961161,0.0007597358,0.00007348648,0.0001673153,0.0001073095,0.0003597353,0.0004148258,0.00003378651],"category_scores_gemma":[0.00007363592,0.0002912758,0.0003573109,0.0002311477,0.0001088035,0.000004587556,0.0001068858,0.0003291834,0.00004910776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006425306,"about_ca_system_score_gemma":0.0004700827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002530957,"about_ca_topic_score_gemma":0.0001032652,"domain_scores_codex":[0.9980019,0.0002632337,0.0004831945,0.0006334762,0.0002603898,0.0003577777],"domain_scores_gemma":[0.9987737,0.00008238955,0.0002993387,0.000688309,0.00008567375,0.00007059215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001071231,0.00004933617,0.000006093663,0.006244866,0.0008313105,0.00002052613,0.0001165462,0.0002445943,0.004777474,0.00003764699,0.001622244,0.9859422],"study_design_scores_gemma":[0.000270766,0.0001921674,9.459438e-7,0.003395752,0.0005593892,0.00009902821,0.00006921808,0.00001749846,0.003603633,0.000001716188,0.9913269,0.0004630032],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001192714,0.995483,0.001469154,0.00006550582,0.0003407414,0.001033517,0.00007816958,0.00003119203,0.0003060459],"genre_scores_gemma":[0.000998985,0.9958352,0.0003449926,0.00007129054,0.0009531525,0.0001534694,0.0008526965,0.0001547162,0.0006354928],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9897046,"threshold_uncertainty_score":0.9999539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04211356981813649,"score_gpt":0.3092820686842081,"score_spread":0.2671684988660716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}