{"id":"W2992627458","doi":"10.1016/j.neuropharm.2019.107902","title":"LSP5-2157 a new inhibitor of vesicular glutamate transporters","year":2019,"lang":"en","type":"article","venue":"Neuropharmacology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Douglas Mental Health University Institute; Douglas College","funders":"European Research Council; Fonds de Recherche du Québec - Santé; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Deutsche Forschungsgemeinschaft; Agence Nationale de la Recherche; Centre National de la Recherche Scientifique; Deutscher Akademischer Austauschdienst; Fédération pour la Recherche sur le Cerveau; Fondation Brain Canada; Ohio State University","keywords":"Glutamatergic; Neurotransmission; Glutamate receptor; Biology; Neuroscience; AMPA receptor; Pharmacology; Metabotropic glutamate receptor; Synaptic vesicle; NMDA receptor; Synaptic cleft; Biochemistry; Receptor; Vesicle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002054858,0.0007131657,0.0005865884,0.0004152693,0.0003469102,0.000512338,0.0006935179,0.0006317282,0.003282524],"category_scores_gemma":[0.0001378355,0.0002230566,0.0005010107,0.0003664835,0.0002384494,0.0003753216,0.0003730015,0.001360602,0.001113234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006064918,"about_ca_system_score_gemma":0.0008647174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001384765,"about_ca_topic_score_gemma":0.002221484,"domain_scores_codex":[0.9998462,0.00001884088,0.00001447424,0.00002719329,0.00003419251,0.00005907733],"domain_scores_gemma":[0.9999598,0.000004793977,0.000005670253,0.000003190287,0.000005721766,0.00002073586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001771963,0.0005097396,0.0004465313,0.0005133274,0.0001317512,0.0008149562,0.00005462108,0.0006212236,0.9439695,0.002404256,0.003509818,0.04525213],"study_design_scores_gemma":[0.001173868,0.00585459,0.004139582,0.00006341983,0.0002177246,0.002753021,0.00004911845,0.002700383,0.9249188,0.000437674,0.05763514,0.0000566973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9113874,0.03343989,0.01314714,0.001581585,0.0009135292,0.0005075501,0.002837458,0.001502154,0.03468318],"genre_scores_gemma":[0.9547461,0.01400942,0.008098953,0.0008029958,0.0001128768,0.0002388699,0.004465532,0.00007259384,0.01745264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003282524,"threshold_uncertainty_score":0.01098114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03192777680643771,"score_gpt":0.3177265825234717,"score_spread":0.285798805717034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}