{"id":"W2992627458","doi":"10.1016/j.neuropharm.2019.107902","title":"LSP5-2157 a new inhibitor of vesicular glutamate transporters","year":2019,"lang":"en","type":"article","venue":"Neuropharmacology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Douglas Mental Health University Institute; Douglas College","funders":"European Research Council; Fonds de Recherche du Québec - Santé; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Deutsche Forschungsgemeinschaft; Agence Nationale de la Recherche; Centre National de la Recherche Scientifique; Deutscher Akademischer Austauschdienst; Fédération pour la Recherche sur le Cerveau; Fondation Brain Canada; Ohio State University","keywords":"Glutamatergic; Neurotransmission; Glutamate receptor; Biology; Neuroscience; AMPA receptor; Pharmacology; Metabotropic glutamate receptor; Synaptic vesicle; NMDA receptor; Synaptic cleft; Biochemistry; Receptor; Vesicle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002082147,0.0003218511,0.000505119,0.0003809941,0.0001224205,0.00002673635,0.0009990443,0.0001219719,0.001988856],"category_scores_gemma":[0.000184412,0.0003051931,0.0002036939,0.00100487,0.0004959509,0.0003296256,0.0001870575,0.0006778258,0.001179715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002702956,"about_ca_system_score_gemma":0.0002830116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001035273,"about_ca_topic_score_gemma":4.320738e-7,"domain_scores_codex":[0.9962785,0.000575517,0.0005576097,0.001085559,0.0006022856,0.0009004982],"domain_scores_gemma":[0.9982557,0.0006430178,0.0002165099,0.000435319,0.00005478908,0.0003946716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000463937,0.0002102115,0.001442375,0.00004285883,0.000006620218,0.0007856743,0.0001014764,0.0001595096,0.9934411,0.0002264609,0.002045889,0.001073889],"study_design_scores_gemma":[0.002470471,0.0008774652,0.001948936,0.000008142746,0.00003429845,0.0001572389,0.000007044424,0.000438703,0.976184,0.00005573488,0.01758478,0.0002332265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99307,0.00004007285,0.00001497982,0.001260865,0.003043388,0.0008418118,0.00002083518,0.0001516573,0.001556403],"genre_scores_gemma":[0.9890317,0.0002787315,0.0000175452,0.007954364,0.0001825662,0.00002144686,5.725876e-7,0.00006111703,0.002451981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01725714,"threshold_uncertainty_score":0.99994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03192777680643771,"score_gpt":0.3177265825234717,"score_spread":0.285798805717034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}